3-((3-((4-chlorophenyl)(phenyl)methylene)-2-oxoindolin-1-yl)methyl)benzoic acid methyl ester

Base Information

Chemical Name:3-((3-((4-chlorophenyl)(phenyl)methylene)-2-oxoindolin-1-yl)methyl)benzoic acid methyl ester
CAS No.:1273323-57-1
Molecular Formula:C₃₀H₂₂ClNO₃
Molecular Weight:479.963
Hs Code.:

Synonyms:3-((3-((4-chlorophenyl)(phenyl)methylene)-2-oxoindolin-1-yl)methyl)benzoic acid methyl ester

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Chemical Property of 3-((3-((4-chlorophenyl)(phenyl)methylene)-2-oxoindolin-1-yl)methyl)benzoic acid methyl ester

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Technology Process of 3-((3-((4-chlorophenyl)(phenyl)methylene)-2-oxoindolin-1-yl)methyl)benzoic acid methyl ester

There total 10 articles about 3-((3-((4-chlorophenyl)(phenyl)methylene)-2-oxoindolin-1-yl)methyl)benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: (Z)-3-((4-chlorophenyl)(phenyl)methylene)indolin-2-one

: 1129-28-8
3-methoxycarbonylbenzyl bromide

: 1273323-57-1
3-((3-((4-chlorophenyl)(phenyl)methylene)-2-oxoindolin-1-yl)methyl)benzoic acid methyl ester

Guidance literature:: (Z)-3-((4-chlorophenyl)(phenyl)methylene)indolin-2-one; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.5h; Cooling with ice;

3-methoxycarbonylbenzyl bromide; In tetrahydrofuran; at 20 ℃; for 3h;
DOI:10.1002/cmdc.202000579

Reference yield:

: 3-((4-chlorophenyl)(phenyl)methylene)indolin-2-one

: 1129-28-8
3-methoxycarbonylbenzyl bromide

: 1273323-27-5
(E)-3-((3-((4-chlorophenyl)(phenyl)methylene)-2-oxoindolin-1-yl)methyl)benzoic acid methyl ester

: 1273323-57-1
3-((3-((4-chlorophenyl)(phenyl)methylene)-2-oxoindolin-1-yl)methyl)benzoic acid methyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; Reagent/catalyst; Solvent; Overall yield = 93 %;
DOI:10.1039/c8ra07576j

Reference yield:

: 637-87-6
1-Chloro-4-iodobenzene

: 1273324-41-6
3-{[phenyl-(3-phenyl-propynoyl)-amino]-methyl}-benzoic acid methyl ester

: 1273323-29-7
methyl 3-((3-(diphenylmethylene)-2-oxoindolin-1-yl)methyl)benzoate

: 1273323-27-5
(E)-3-((3-((4-chlorophenyl)(phenyl)methylene)-2-oxoindolin-1-yl)methyl)benzoic acid methyl ester

: 1273323-57-1
3-((3-((4-chlorophenyl)(phenyl)methylene)-2-oxoindolin-1-yl)methyl)benzoic acid methyl ester

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In N,N-dimethyl-formamide; at 110 ℃; for 7h; Reagent/catalyst; Inert atmosphere;
DOI:10.1021/acs.oprd.1c00150