N'-(2-(tert-butyldimethylsilyloxy)-2-(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)acetyl)picolinohydrazide

Base Information

Chemical Name:N'-(2-(tert-butyldimethylsilyloxy)-2-(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)acetyl)picolinohydrazide
CAS No.:1289564-62-0
Molecular Formula:C₃₀H₃₇N₃O₄Si
Molecular Weight:531.727
Hs Code.:

Synonyms:N'-(2-(tert-butyldimethylsilyloxy)-2-(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)acetyl)picolinohydrazide

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Chemical Property of N'-(2-(tert-butyldimethylsilyloxy)-2-(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)acetyl)picolinohydrazide

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Technology Process of N'-(2-(tert-butyldimethylsilyloxy)-2-(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)acetyl)picolinohydrazide

There total 13 articles about N'-(2-(tert-butyldimethylsilyloxy)-2-(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)acetyl)picolinohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1452-63-7
picolinic acid hydrazide

: 1289564-52-8
2-(tert-butyldimethylsilyloxy)-2-(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)acetic acid

: 1289564-62-0
N'-(2-(tert-butyldimethylsilyloxy)-2-(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)acetyl)picolinohydrazide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1021/jm101597x

Reference yield:

: 1289564-46-0
2-hydroxy-2-(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)acetonitrile

: 1289564-62-0
N'-(2-(tert-butyldimethylsilyloxy)-2-(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)acetyl)picolinohydrazide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / ethyl acetate / 16 h / Reflux; Inert atmosphere

2: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C

3: water; lithium hydroxide / tetrahydrofuran; methanol / 16 h / 20 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C

With 1H-imidazole; hydrogenchloride; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm101597x

Reference yield:

: 1289564-48-2
methyl 2-hydroxy-2-(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)acetate

: 1289564-62-0
N'-(2-(tert-butyldimethylsilyloxy)-2-(6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)acetyl)picolinohydrazide

Guidance literature:: Multi-step reaction with 3 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C

2: water; lithium hydroxide / tetrahydrofuran; methanol / 16 h / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C

With 1H-imidazole; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm101597x