Technology Process of (6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)(5-(pyridin-2-yl)-1,3,4-oxadiazol-2-yl)methanone
There total 18 articles about (6-phenoxy-1,2,3,4-tetrahydronaphthalen-2-yl)(5-(pyridin-2-yl)-1,3,4-oxadiazol-2-yl)methanone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
Dess-Martin periodane;
In
dichloromethane;
at 20 ℃;
for 2h;
DOI:10.1021/jm101597x
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: copper diacetate / dichloromethane / 0.25 h / 20 °C / Molecular sieve
1.2: 17 h / 20 °C / Inert atmosphere
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
3.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C
4.1: tetrahydrofuran; water / 16 h / 20 °C
5.1: hydrogenchloride / ethyl acetate / 16 h / Reflux; Inert atmosphere
6.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C
7.1: water; lithium hydroxide / tetrahydrofuran; methanol / 16 h / 20 °C
8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C
9.1: triethylamine; p-toluenesulfonyl chloride / dichloromethane / 16 h / 20 °C
10.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere
11.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C
With
1H-imidazole; hydrogenchloride; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; water; copper diacetate; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; p-toluenesulfonyl chloride; lithium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm101597x
