5-(ethylpiperidin-4-ylamino)-4-methyl-4′-morpholin-4-ylmethylbiphenyl-3-carboxylic acid (4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-ylmethyl)amide

Base Information

Chemical Name:5-(ethylpiperidin-4-ylamino)-4-methyl-4′-morpholin-4-ylmethylbiphenyl-3-carboxylic acid (4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-ylmethyl)amide
CAS No.:1403255-97-9
Molecular Formula:C₃₄H₄₅N₅O₃
Molecular Weight:571.763
Hs Code.:

5-(ethylpiperidin-4-ylamino)-4-methyl-4′-morpholin-4-ylmethylbiphenyl-3-carboxylic acid (4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-ylmethyl)amide

Synonyms:5-(ethylpiperidin-4-ylamino)-4-methyl-4′-morpholin-4-ylmethylbiphenyl-3-carboxylic acid (4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-ylmethyl)amide

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Chemical Property of 5-(ethylpiperidin-4-ylamino)-4-methyl-4′-morpholin-4-ylmethylbiphenyl-3-carboxylic acid (4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-ylmethyl)amide

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Technology Process of 5-(ethylpiperidin-4-ylamino)-4-methyl-4′-morpholin-4-ylmethylbiphenyl-3-carboxylic acid (4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-ylmethyl)amide

There total 10 articles about 5-(ethylpiperidin-4-ylamino)-4-methyl-4′-morpholin-4-ylmethylbiphenyl-3-carboxylic acid (4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-ylmethyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.81%

: 1403255-98-0
tert-butyl 4-((5-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-4-methyl-4'-(morpholinomethyl)[1,1'-biphenyl]-3-yl)(ethyl)amino)piperidine-1-carboxylate

: 1403255-97-9
5-(ethylpiperidin-4-ylamino)-4-methyl-4′-morpholin-4-ylmethylbiphenyl-3-carboxylic acid (4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-ylmethyl)amide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 2h;

Reference yield:

: 107650-20-4
5-bromo-2-methyl-3-nitro-benzoic acid

: 1403255-97-9
5-(ethylpiperidin-4-ylamino)-4-methyl-4′-morpholin-4-ylmethylbiphenyl-3-carboxylic acid (4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-ylmethyl)amide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C

2.1: ammonium chloride; iron / ethanol; water / 7 h / 80 °C

3.1: acetic acid / 1,1-dichloroethane / 0.17 h / 20 °C

3.2: 0 - 20 °C

4.1: acetic acid / 1,1-dichloroethane / 0.17 h / 20 °C

4.2: 2 h / 0 - 20 °C

5.1: sodium hydroxide; water / ethanol / 1 h / 60 °C

5.2: pH 6

5.3: pH 4

6.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dimethyl sulfoxide / 20 °C

7.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 3.5 h / 90 °C / Inert atmosphere

8.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; iron; sodium carbonate; ammonium chloride; acetic acid; trifluoroacetic acid; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; 1,1-dichloroethane; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; 7.1: Suzuki Coupling;

Reference yield:

: 220514-28-3
5-bromo-2-methyl-3-nitrobenzoic acid methyl ester

: 1403255-97-9
5-(ethylpiperidin-4-ylamino)-4-methyl-4′-morpholin-4-ylmethylbiphenyl-3-carboxylic acid (4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-ylmethyl)amide

Guidance literature:: Multi-step reaction with 7 steps

1.1: ammonium chloride; iron / ethanol; water / 7 h / 80 °C

2.1: acetic acid / 1,1-dichloroethane / 0.17 h / 20 °C

2.2: 0 - 20 °C

3.1: acetic acid / 1,1-dichloroethane / 0.17 h / 20 °C

3.2: 2 h / 0 - 20 °C

4.1: sodium hydroxide; water / ethanol / 1 h / 60 °C

4.2: pH 6

4.3: pH 4

5.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dimethyl sulfoxide / 20 °C

6.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 3.5 h / 90 °C / Inert atmosphere

7.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; iron; sodium carbonate; ammonium chloride; acetic acid; trifluoroacetic acid; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; 1,1-dichloroethane; ethanol; dichloromethane; water; dimethyl sulfoxide; 6.1: Suzuki Coupling;