(R)-1-cyclopropyl-3-(4-(5-(2,2-difluoropropyl)-6a-methyl-6-oxo-5,6,6a,7,9,10-hexahydro[1,4]oxazino[3,4-h]pteridin-2-yl)phenyl)urea

Base Information

Chemical Name:(R)-1-cyclopropyl-3-(4-(5-(2,2-difluoropropyl)-6a-methyl-6-oxo-5,6,6a,7,9,10-hexahydro[1,4]oxazino[3,4-h]pteridin-2-yl)phenyl)urea
CAS No.:1268474-32-3
Molecular Formula:C₂₃H₂₆F₂N₆O₃
Molecular Weight:472.495
Hs Code.:

Synonyms:(R)-1-cyclopropyl-3-(4-(5-(2,2-difluoropropyl)-6a-methyl-6-oxo-5,6,6a,7,9,10-hexahydro[1,4]oxazino[3,4-h]pteridin-2-yl)phenyl)urea

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Chemical Property of (R)-1-cyclopropyl-3-(4-(5-(2,2-difluoropropyl)-6a-methyl-6-oxo-5,6,6a,7,9,10-hexahydro[1,4]oxazino[3,4-h]pteridin-2-yl)phenyl)urea

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Technology Process of (R)-1-cyclopropyl-3-(4-(5-(2,2-difluoropropyl)-6a-methyl-6-oxo-5,6,6a,7,9,10-hexahydro[1,4]oxazino[3,4-h]pteridin-2-yl)phenyl)urea

There total 7 articles about (R)-1-cyclopropyl-3-(4-(5-(2,2-difluoropropyl)-6a-methyl-6-oxo-5,6,6a,7,9,10-hexahydro[1,4]oxazino[3,4-h]pteridin-2-yl)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 256446-67-0,819078-65-4
4-((benzyloxy)carbonyl)morpholine-3-carboxylic acid

: 1268474-32-3
(R)-1-cyclopropyl-3-(4-(5-(2,2-difluoropropyl)-6a-methyl-6-oxo-5,6,6a,7,9,10-hexahydro[1,4]oxazino[3,4-h]pteridin-2-yl)phenyl)urea

: 1268474-30-1
(S)-1-cyclopropyl-3-(4-(5-(2,2-difluoropropyl)-6a-methyl-6-oxo-5,6,6a,7,9,10-hexahydro[1,4]oxazino[3,4-h]pteridin-2-yl)phenyl)urea

Guidance literature:: Multi-step reaction with 8 steps

1: sulfuric acid / 18 h / 34 - 50 °C

2: sodium hexamethyldisilazane / tetrahydrofuran / 5.03 h / -70 - -40 °C

3: hydrogen / palladium 10% on activated carbon / ethanol / 16 h / 760.05 Torr / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 h / -10 - 20 °C

5: methanol / bis(acetylacetonate)oxovanadium / tetrahydrofuran / 18 h / 20 - 35 °C / 760.05 Torr

6: caesium carbonate / ISOPROPYLAMIDE / 23 h / 20 - 60 °C

7: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.5 h / 110 °C / Microwave Irradiation

8: ammonium acetate / carbon dioxide; propan-1-ol / Resolution of racemate

With methanol; sulfuric acid; ammonium acetate; hydrogen; sodium hexamethyldisilazane; sodium hydrogencarbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; bis(acetylacetonate)oxovanadium; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; propan-1-ol; ethanol; ISOPROPYLAMIDE; carbon dioxide; water;

Reference yield:

: 77873-76-8,106825-81-4
morpholine-3-carboxylic acid

: 1268474-32-3
(R)-1-cyclopropyl-3-(4-(5-(2,2-difluoropropyl)-6a-methyl-6-oxo-5,6,6a,7,9,10-hexahydro[1,4]oxazino[3,4-h]pteridin-2-yl)phenyl)urea

: 1268474-30-1
(S)-1-cyclopropyl-3-(4-(5-(2,2-difluoropropyl)-6a-methyl-6-oxo-5,6,6a,7,9,10-hexahydro[1,4]oxazino[3,4-h]pteridin-2-yl)phenyl)urea

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 100 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C

3.1: diethylamino-sulfur trifluoride / dichloromethane / 25 h / 0 - 20 °C

3.2: 0.25 h / 0 °C

4.1: sodium t-butanolate / dimethyl sulfoxide / 16 h / 0 - 20 °C

5.1: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.5 h / 110 °C / Microwave Irradiation

6.1: ammonium acetate / carbon dioxide; propan-1-ol / Resolution of racemate

With diethylamino-sulfur trifluoride; ammonium acetate; sodium hydrogencarbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium t-butanolate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; propan-1-ol; dichloromethane; carbon dioxide; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1268474-50-5
2-chloro-6a,7,9,10-tetrahydro[1,4]oxazino[3,4-h]pteridin -6(5H)-one

: 1268474-32-3
(R)-1-cyclopropyl-3-(4-(5-(2,2-difluoropropyl)-6a-methyl-6-oxo-5,6,6a,7,9,10-hexahydro[1,4]oxazino[3,4-h]pteridin-2-yl)phenyl)urea

: 1268474-30-1
(S)-1-cyclopropyl-3-(4-(5-(2,2-difluoropropyl)-6a-methyl-6-oxo-5,6,6a,7,9,10-hexahydro[1,4]oxazino[3,4-h]pteridin-2-yl)phenyl)urea

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C

2.1: diethylamino-sulfur trifluoride / dichloromethane / 25 h / 0 - 20 °C

2.2: 0.25 h / 0 °C

3.1: sodium t-butanolate / dimethyl sulfoxide / 16 h / 0 - 20 °C

4.1: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.5 h / 110 °C / Microwave Irradiation

5.1: ammonium acetate / carbon dioxide; propan-1-ol / Resolution of racemate

With diethylamino-sulfur trifluoride; ammonium acetate; sodium hydrogencarbonate; potassium carbonate; sodium t-butanolate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; propan-1-ol; dichloromethane; carbon dioxide; water; dimethyl sulfoxide; N,N-dimethyl-formamide;