2-chloro-5-(2,2-difluoropropyl)-6a-methyl-6a,7,9,10-tetrahydro[1,4]oxazino[3,4-h]pteridin-6(5H)-one

Base Information

Chemical Name:2-chloro-5-(2,2-difluoropropyl)-6a-methyl-6a,7,9,10-tetrahydro[1,4]oxazino[3,4-h]pteridin-6(5H)-one
CAS No.:1268475-08-6
Molecular Formula:C₁₃H₁₅ClF₂N₄O₂
Molecular Weight:332.738
Hs Code.:

Synonyms:2-chloro-5-(2,2-difluoropropyl)-6a-methyl-6a,7,9,10-tetrahydro[1,4]oxazino[3,4-h]pteridin-6(5H)-one

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Chemical Property of 2-chloro-5-(2,2-difluoropropyl)-6a-methyl-6a,7,9,10-tetrahydro[1,4]oxazino[3,4-h]pteridin-6(5H)-one

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Technology Process of 2-chloro-5-(2,2-difluoropropyl)-6a-methyl-6a,7,9,10-tetrahydro[1,4]oxazino[3,4-h]pteridin-6(5H)-one

There total 1 articles about 2-chloro-5-(2,2-difluoropropyl)-6a-methyl-6a,7,9,10-tetrahydro[1,4]oxazino[3,4-h]pteridin-6(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 256446-67-0,819078-65-4
4-((benzyloxy)carbonyl)morpholine-3-carboxylic acid

: 1268475-08-6
2-chloro-5-(2,2-difluoropropyl)-6a-methyl-6a,7,9,10-tetrahydro[1,4]oxazino[3,4-h]pteridin-6(5H)-one

Guidance literature:: Multi-step reaction with 6 steps

1: sulfuric acid / 18 h / 34 - 50 °C

2: sodium hexamethyldisilazane / tetrahydrofuran / 5.03 h / -70 - -40 °C

3: hydrogen / palladium 10% on activated carbon / ethanol / 16 h / 760.05 Torr / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 h / -10 - 20 °C

5: methanol / bis(acetylacetonate)oxovanadium / tetrahydrofuran / 18 h / 20 - 35 °C / 760.05 Torr

6: caesium carbonate / ISOPROPYLAMIDE / 23 h / 20 - 60 °C

With methanol; sulfuric acid; hydrogen; sodium hexamethyldisilazane; caesium carbonate; N-ethyl-N,N-diisopropylamine; bis(acetylacetonate)oxovanadium; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; ISOPROPYLAMIDE;

Reference yield: 44.0%

: 874297-79-7
1-cyclopropyl-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea

: 1268475-08-6
2-chloro-5-(2,2-difluoropropyl)-6a-methyl-6a,7,9,10-tetrahydro[1,4]oxazino[3,4-h]pteridin-6(5H)-one

: 1268474-29-8
1-cyclopropyl-3-(4-(5-(2,2-difluoropropyl)-6a-methyl-6-oxo-5,6,6a,7,9,10-hexahydro[1,4]oxazino[3,4-h]pteridin-2-yl)phenyl)urea

Guidance literature:: With sodium hydrogencarbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; at 110 ℃; for 0.5h; Product distribution / selectivity; Microwave Irradiation;

Reference yield:

: 874297-79-7
1-cyclopropyl-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea

: 1268475-08-6
2-chloro-5-(2,2-difluoropropyl)-6a-methyl-6a,7,9,10-tetrahydro[1,4]oxazino[3,4-h]pteridin-6(5H)-one

: 1268474-32-3
(R)-1-cyclopropyl-3-(4-(5-(2,2-difluoropropyl)-6a-methyl-6-oxo-5,6,6a,7,9,10-hexahydro[1,4]oxazino[3,4-h]pteridin-2-yl)phenyl)urea

: 1268474-30-1
(S)-1-cyclopropyl-3-(4-(5-(2,2-difluoropropyl)-6a-methyl-6-oxo-5,6,6a,7,9,10-hexahydro[1,4]oxazino[3,4-h]pteridin-2-yl)phenyl)urea

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.5 h / 110 °C / Microwave Irradiation

2: ammonium acetate / carbon dioxide; propan-1-ol / Resolution of racemate

With ammonium acetate; sodium hydrogencarbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; propan-1-ol; carbon dioxide; water;