(1R,2R)-2-(4-fluorophenyl)cyclopropanecarboxylic acid [(R)-cyclopropyl-(4-difluoromethoxyphenyl)methyl]pyridazin-3-ylmethylamide

Base Information

Chemical Name:(1R,2R)-2-(4-fluorophenyl)cyclopropanecarboxylic acid [(R)-cyclopropyl-(4-difluoromethoxyphenyl)methyl]pyridazin-3-ylmethylamide
CAS No.:1414775-40-8
Molecular Formula:C₂₆H₂₄F₃N₃O₂
Molecular Weight:467.491
Hs Code.:

Synonyms:(1R,2R)-2-(4-fluorophenyl)cyclopropanecarboxylic acid [(R)-cyclopropyl-(4-difluoromethoxyphenyl)methyl]pyridazin-3-ylmethylamide

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Chemical Property of (1R,2R)-2-(4-fluorophenyl)cyclopropanecarboxylic acid [(R)-cyclopropyl-(4-difluoromethoxyphenyl)methyl]pyridazin-3-ylmethylamide

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Technology Process of (1R,2R)-2-(4-fluorophenyl)cyclopropanecarboxylic acid [(R)-cyclopropyl-(4-difluoromethoxyphenyl)methyl]pyridazin-3-ylmethylamide

There total 9 articles about (1R,2R)-2-(4-fluorophenyl)cyclopropanecarboxylic acid [(R)-cyclopropyl-(4-difluoromethoxyphenyl)methyl]pyridazin-3-ylmethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: C₁₀H₈ClFO

: 1213625-74-1
(R)-{cyclopropyl[4-(difluoromethoxy)phenyl]methyl}amine

: 1414775-40-8
(1R,2R)-2-(4-fluorophenyl)cyclopropanecarboxylic acid [(R)-cyclopropyl-(4-difluoromethoxyphenyl)methyl]pyridazin-3-ylmethylamide

Guidance literature:: With pyridine; at 20 ℃; for 20h;

Reference yield:

: 1414778-35-0
[(R)-cyclopropyl-(4-difluoromethoxyphenyl)methyl]pyridazin-3-ylmethylarnine

: 161711-27-9,515179-19-8,879324-64-8
(1R,2R)-2-(4-fluorophenyl)cyclopropanecarboxylic acid

: 1414775-40-8
(1R,2R)-2-(4-fluorophenyl)cyclopropanecarboxylic acid [(R)-cyclopropyl-(4-difluoromethoxyphenyl)methyl]pyridazin-3-ylmethylamide

Guidance literature:: [(R)-cyclopropyl-(4-difluoromethoxyphenyl)methyl]pyridazin-3-ylmethylarnine; (1R,2R)-2-(4-fluorophenyl)cyclopropanecarboxylic acid; With N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; at 0 ℃; for 0.25h;

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In 1,2-dichloro-ethane; at 0 - 60 ℃; for 5.25h;

Reference yield:

: {cyclopropyl[4-(difluoromethoxy)phenyl]methyl}amine

: 1414775-40-8
(1R,2R)-2-(4-fluorophenyl)cyclopropanecarboxylic acid [(R)-cyclopropyl-(4-difluoromethoxyphenyl)methyl]pyridazin-3-ylmethylamide

Guidance literature:: Multi-step reaction with 2 steps

1: Chiracel OD-H / hexane; diethylamine; isopropyl alcohol / Resolution of racemate

2: pyridine / 20 h / 20 °C

With pyridine; In hexane; diethylamine; isopropyl alcohol;