[(R)-cyclopropyl-(4-difluoromethoxyphenyl)methyl]pyridazin-3-ylmethylarnine

Base Information

Chemical Name:[(R)-cyclopropyl-(4-difluoromethoxyphenyl)methyl]pyridazin-3-ylmethylarnine
CAS No.:1414778-35-0
Molecular Formula:C₁₆H₁₇F₂N₃O
Molecular Weight:305.327
Hs Code.:

Synonyms:[(R)-cyclopropyl-(4-difluoromethoxyphenyl)methyl]pyridazin-3-ylmethylarnine

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Chemical Property of [(R)-cyclopropyl-(4-difluoromethoxyphenyl)methyl]pyridazin-3-ylmethylarnine

Chemical Property:

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Technology Process of [(R)-cyclopropyl-(4-difluoromethoxyphenyl)methyl]pyridazin-3-ylmethylarnine

There total 2 articles about [(R)-cyclopropyl-(4-difluoromethoxyphenyl)methyl]pyridazin-3-ylmethylarnine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1213315-68-4
(S)-{cyclopropyl[4-(difluoromethoxy)phenyl]methyl}amine

: 60170-83-4
pyridazine-3 carboxaldehyde

: 1414778-35-0
[(R)-cyclopropyl-(4-difluoromethoxyphenyl)methyl]pyridazin-3-ylmethylarnine

Guidance literature:: (S)-{cyclopropyl[4-(difluoromethoxy)phenyl]methyl}amine; pyridazine-3 carboxaldehyde; With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; at 20 - 35 ℃; Inert atmosphere;

With potassium carbonate; In water; 1,2-dichloro-ethane;

Reference yield:

: {cyclopropyl[4-(difluoromethoxy)phenyl]methyl}amine

: 1414778-35-0
[(R)-cyclopropyl-(4-difluoromethoxyphenyl)methyl]pyridazin-3-ylmethylarnine

Guidance literature:: Multi-step reaction with 2 steps

1: Chiracel OD-H / hexane; diethylamine; isopropyl alcohol / Resolution of racemate

2: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 20 - 35 °C / Inert atmosphere

With sodium tris(acetoxy)borohydride; acetic acid; In hexane; 1,2-dichloro-ethane; diethylamine; isopropyl alcohol;

Reference yield:

: 1414778-35-0
[(R)-cyclopropyl-(4-difluoromethoxyphenyl)methyl]pyridazin-3-ylmethylarnine

: 161711-27-9,515179-19-8,879324-64-8
(1R,2R)-2-(4-fluorophenyl)cyclopropanecarboxylic acid

: 1414775-40-8
(1R,2R)-2-(4-fluorophenyl)cyclopropanecarboxylic acid [(R)-cyclopropyl-(4-difluoromethoxyphenyl)methyl]pyridazin-3-ylmethylamide

Guidance literature:: [(R)-cyclopropyl-(4-difluoromethoxyphenyl)methyl]pyridazin-3-ylmethylarnine; (1R,2R)-2-(4-fluorophenyl)cyclopropanecarboxylic acid; With N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; at 0 ℃; for 0.25h;

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In 1,2-dichloro-ethane; at 0 - 60 ℃; for 5.25h;