Technology Process of N-acetylazacorrole
There total 4 articles about N-acetylazacorrole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydride;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 5.5h;
regioselective reaction;
Inert atmosphere;
DOI:10.1002/chem.201200485
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 1 h / 20 °C
1.2: 24 h / 20 °C
2.1: potassium tert-butylate; palladium diacetate; XPhos / toluene / 20 h / 20 - 100 °C / Inert atmosphere
3.1: sodium hydride / tetrahydrofuran / 5.5 h / 0 - 20 °C / Inert atmosphere
With
potassium tert-butylate; palladium diacetate; sodium hydride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; XPhos;
In
tetrahydrofuran; dichloromethane; toluene;
2.1: Buchwald-Hartwig amination;
DOI:10.1002/chem.201200485
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: N-chloro-succinimide / tetrahydrofuran / 5 h / -78 - 20 °C
2.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 1 h / 20 °C
2.2: 24 h / 20 °C
3.1: potassium tert-butylate; palladium diacetate; XPhos / toluene / 20 h / 20 - 100 °C / Inert atmosphere
4.1: sodium hydride / tetrahydrofuran / 5.5 h / 0 - 20 °C / Inert atmosphere
With
N-chloro-succinimide; potassium tert-butylate; palladium diacetate; sodium hydride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; XPhos;
In
tetrahydrofuran; dichloromethane; toluene;
3.1: Buchwald-Hartwig amination;
DOI:10.1002/chem.201200485
