Technology Process of 7-bromo-5,5-difluoro-10-(p-tolyl)-5H-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-4-ium-5-uide
There total 3 articles about 7-bromo-5,5-difluoro-10-(p-tolyl)-5H-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-4-ium-5-uide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-(4-methylphenyl)dipyrromethane;
With
N-Bromosuccinimide;
In
tetrahydrofuran;
at -78 ℃;
for 1h;
Inert atmosphere;
With
2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
tetrahydrofuran;
at 20 ℃;
Inert atmosphere;
With
boron trifluoride diethyl etherate; triethylamine;
In
dichloromethane;
at 20 ℃;
for 1h;
Inert atmosphere;
DOI:10.1016/j.tetlet.2013.11.003
- Guidance literature:
-
With
Et3N;
In
dichloromethane;
N compd. dissolved in CH2Cl2, Et3N (75.4 mmol), B compd. (107 mmol) wereadded, 25 °C for 1 h.; washed with NaOH soln. and water, dried over Na2SO4, filtered and evap.,TLC, column chromy. (petroleum ether/CH2Cl2, 90/10); elem. anal.;
DOI:10.1016/j.jorganchem.2010.01.009
