1-[2-(1-benzyloxy-allyl)-3-(tert-butyl-dimethyl-silanyloxy)-3,6-dihydro-2H-pyridin-1-yl]-ethanone

Base Information

• Chemical Name: 1-[2-(1-benzyloxy-allyl)-3-(tert-butyl-dimethyl-silanyloxy)-3,6-dihydro-2H-pyridin-1-yl]-ethanone
• CAS No.: 791821-61-9
• Molecular Formula: C₂₃H₃₅NO₃Si
• Molecular Weight: 401.621
• Mol file: 791821-61-9.mol

Synonyms:1-[2-(1-benzyloxy-allyl)-3-(tert-butyl-dimethyl-silanyloxy)-3,6-dihydro-2H-pyridin-1-yl]-ethanone

Chemical Property of 1-[2-(1-benzyloxy-allyl)-3-(tert-butyl-dimethyl-silanyloxy)-3,6-dihydro-2H-pyridin-1-yl]-ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[2-(1-benzyloxy-allyl)-3-(tert-butyl-dimethyl-silanyloxy)-3,6-dihydro-2H-pyridin-1-yl]-ethanone

There total 1 articles about 1-[2-(1-benzyloxy-allyl)-3-(tert-butyl-dimethyl-silanyloxy)-3,6-dihydro-2H-pyridin-1-yl]-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

ethene (74-85-1) + N-allyl-N-[2-benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-cyclopent-3-enyl]-acetamide → 1-[2-(1-benzyloxy-allyl)-3-(tert-butyl-dimethyl-silanyloxy)-3,6-dihydro-2H-pyridin-1-yl]-ethanone (791821-61-9) + N-(4-{acetyl-[2-benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-cyclopent-3-enyl]-amino}-but-2-enyl)-N-[2-benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-cyclopent-3-enyl]-acetamide

Guidance literature:

tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; for 16h; Heating;

DOI:10.1021/jo040226a

Reference yield:

1-[2-(1-benzyloxy-allyl)-3-(tert-butyl-dimethyl-silanyloxy)-3,6-dihydro-2H-pyridin-1-yl]-ethanone (791821-61-9) → 1-[(2S,3R)-2-((S)-1-Benzyloxy-allyl)-3-hydroxy-3,6-dihydro-2H-pyridin-1-yl]-ethanone

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 25 ℃; for 2h;

DOI:10.1021/jo040226a

Reference yield:

1-[2-(1-benzyloxy-allyl)-3-(tert-butyl-dimethyl-silanyloxy)-3,6-dihydro-2H-pyridin-1-yl]-ethanone (791821-61-9) → Acetic acid (2R,3R)-1-acetyl-2-((S)-1-benzyloxy-allyl)-1,2,3,6-tetrahydro-pyridin-3-yl ester

Guidance literature:

Multi-step reaction with 2 steps

1: TBAF / tetrahydrofuran / 2 h / 25 °C

2: 7 mg / pyridine; DMAP / CH₂Cl₂ / 25 °C

With pyridine; dmap; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo040226a

upstream raw materials:

ethene