(1S,2R,3R,5R)-2-((4-chlorophen)ethyl)-1,4,4-trimethyl-8-oxabicyclo[3.2.1]octan-3-ol

Base Information

Chemical Name:(1S,2R,3R,5R)-2-((4-chlorophen)ethyl)-1,4,4-trimethyl-8-oxabicyclo[3.2.1]octan-3-ol
CAS No.:1402735-93-6
Molecular Formula:C₁₈H₂₅ClO₂
Molecular Weight:308.848
Hs Code.:

Synonyms:(1S,2R,3R,5R)-2-((4-chlorophen)ethyl)-1,4,4-trimethyl-8-oxabicyclo[3.2.1]octan-3-ol

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Chemical Property of (1S,2R,3R,5R)-2-((4-chlorophen)ethyl)-1,4,4-trimethyl-8-oxabicyclo[3.2.1]octan-3-ol

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Technology Process of (1S,2R,3R,5R)-2-((4-chlorophen)ethyl)-1,4,4-trimethyl-8-oxabicyclo[3.2.1]octan-3-ol

There total 3 articles about (1S,2R,3R,5R)-2-((4-chlorophen)ethyl)-1,4,4-trimethyl-8-oxabicyclo[3.2.1]octan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1402735-96-9
(((1S,2R,3R,5R)-2-((4-chlorophen)ethyl)-1,4,4-trimethyl-8-oxabicyclo[3.2.1]octan-3-yl)oxy)triisopropylsilane

: 1402735-93-6
(1S,2R,3R,5R)-2-((4-chlorophen)ethyl)-1,4,4-trimethyl-8-oxabicyclo[3.2.1]octan-3-ol

Guidance literature:: (((1S,2R,3R,5R)-2-((4-chlorophen)ethyl)-1,4,4-trimethyl-8-oxabicyclo[3.2.1]octan-3-yl)oxy)triisopropylsilane; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; for 12h;

With ammonium chloride; In tetrahydrofuran;
DOI:10.1002/anie.201202699

Reference yield:

: 1402736-17-7
(4R,5R)-2-((E)-6-(4-chlorophenyl)-3-methylhex-3-en-1-yl)-4,5-dimethyl-1,3-dioxolane

: 1402735-93-6
(1S,2R,3R,5R)-2-((4-chlorophen)ethyl)-1,4,4-trimethyl-8-oxabicyclo[3.2.1]octan-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1: titanium tetrachloride / dichloromethane / 10 h / -78 °C / Molecular sieve

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 0 - 20 °C

With tetrabutyl ammonium fluoride; titanium tetrachloride; In tetrahydrofuran; dichloromethane;
DOI:10.1002/anie.201202699

Reference yield:

: 1402736-34-8
C₁₈H₂₇ClO₂

: 1402735-93-6
(1S,2R,3R,5R)-2-((4-chlorophen)ethyl)-1,4,4-trimethyl-8-oxabicyclo[3.2.1]octan-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / dichloromethane / 5 h / 20 °C

2: titanium tetrachloride / dichloromethane / 10 h / -78 °C / Molecular sieve

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 0 - 20 °C

With tetrabutyl ammonium fluoride; titanium tetrachloride; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1002/anie.201202699