3-(2-methoxy-4-methoxycarbonyl-benzyl)-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridine-2-carboxylic acid methyl ester

Base Information

Chemical Name:3-(2-methoxy-4-methoxycarbonyl-benzyl)-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridine-2-carboxylic acid methyl ester
CAS No.:1402345-18-9
Molecular Formula:C₂₆H₂₂N₂O₆
Molecular Weight:458.47
Hs Code.:

Synonyms:3-(2-methoxy-4-methoxycarbonyl-benzyl)-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridine-2-carboxylic acid methyl ester

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Chemical Property of 3-(2-methoxy-4-methoxycarbonyl-benzyl)-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridine-2-carboxylic acid methyl ester

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Technology Process of 3-(2-methoxy-4-methoxycarbonyl-benzyl)-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridine-2-carboxylic acid methyl ester

There total 10 articles about 3-(2-methoxy-4-methoxycarbonyl-benzyl)-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridine-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1402345-17-8
3-methoxy-4-{3-[2-(methoxyoxalyl-phenyl-amino)-pyridin-3-yl]-3-oxo-propyl}-benzoic acid methyl ester

: 1402345-18-9
3-(2-methoxy-4-methoxycarbonyl-benzyl)-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridine-2-carboxylic acid methyl ester

: C₂₅H₁₉N₂O₆^(1-)*K⁽¹⁺⁾

Guidance literature:: With potassium carbonate; In methanol; at 85 ℃; for 2h;

Reference yield:

: 55676-21-6
3-acetyl-2-chloropyridine

: 1402345-18-9
3-(2-methoxy-4-methoxycarbonyl-benzyl)-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: DL-10-camphorsulfonic acid / 1,4-dioxane / 3 h / 75 - 80 °C / Sealed tube

2: sodium methylate / methanol / 48 h / 25 °C

3: hydrogen / palladium 10% on activated carbon / dichloromethane; ethyl acetate; acetone

4: toluene / 4 h / 130 °C

5: potassium carbonate / methanol / 2 h / 85 °C

With hydrogen; sodium methylate; potassium carbonate; palladium 10% on activated carbon; DL-10-camphorsulfonic acid; In 1,4-dioxane; methanol; dichloromethane; ethyl acetate; acetone; toluene; 2: Aldol Condensation;

Reference yield:

: 619-12-5
4-formyl-3-hydroxybenzoic acid

: 1402345-18-9
3-(2-methoxy-4-methoxycarbonyl-benzyl)-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / dimethyl sulfoxide / 4 h / 25 °C

2: sodium methylate / methanol / 48 h / 25 °C

3: hydrogen / palladium 10% on activated carbon / dichloromethane; ethyl acetate; acetone

4: toluene / 4 h / 130 °C

5: potassium carbonate / methanol / 2 h / 85 °C

With hydrogen; sodium methylate; potassium carbonate; palladium 10% on activated carbon; In methanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; acetone; toluene; 2: Aldol Condensation;