ethyl 2-((3-cyano-6-(phenyl)-4-(trifluoromethyl)pyridin-2-yl)oxy)acetate

Base Information

• Chemical Name: ethyl 2-((3-cyano-6-(phenyl)-4-(trifluoromethyl)pyridin-2-yl)oxy)acetate
• CAS No.: 155635-64-6
• Molecular Formula: C₁₇H₁₃F₃N₂O₃
• Molecular Weight: 350.297
• Mol file: 155635-64-6.mol

Synonyms:ethyl 2-((3-cyano-6-(phenyl)-4-(trifluoromethyl)pyridin-2-yl)oxy)acetate

Chemical Property of ethyl 2-((3-cyano-6-(phenyl)-4-(trifluoromethyl)pyridin-2-yl)oxy)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-((3-cyano-6-(phenyl)-4-(trifluoromethyl)pyridin-2-yl)oxy)acetate

There total 2 articles about ethyl 2-((3-cyano-6-(phenyl)-4-(trifluoromethyl)pyridin-2-yl)oxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.5%

2-oxo-6-phenyl-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile (3335-44-2) + ethyl bromoacetate (105-36-2) → ethyl 2-((3-cyano-6-(phenyl)-4-(trifluoromethyl)pyridin-2-yl)oxy)acetate (155635-64-6)

Guidance literature:

With potassium carbonate; sodium iodide; In acetone; at 60 ℃; for 4h;

DOI:10.1016/0022-1139(94)03079-0

Reference yield:

1-Phenyl-4,4,4-trifluorobutane-1,3-dione (326-06-7) → ethyl 2-((3-cyano-6-(phenyl)-4-(trifluoromethyl)pyridin-2-yl)oxy)acetate (155635-64-6)

Guidance literature:

Multi-step reaction with 2 steps

1: piperidine / ethanol / Reflux

2: potassium carbonate; sodium iodide / acetone / 6 h / Reflux

With piperidine; potassium carbonate; sodium iodide; In ethanol; acetone;

DOI:10.1016/j.bmcl.2018.04.031

Reference yield: 96.0%

ethyl 2-((3-cyano-6-(phenyl)-4-(trifluoromethyl)pyridin-2-yl)oxy)acetate (155635-64-6) → 2-O-ethoxy-3-cyano-4-trifluoromethyl-6-phenylpyridine

Guidance literature:

With potassium hydroxide; In ethanol; for 2h; Heating;

DOI:10.1016/0022-1139(93)02936-9

upstream raw materials:

2-oxo-6-phenyl-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile

ethyl bromoacetate

1-Phenyl-4,4,4-trifluorobutane-1,3-dione

Downstream raw materials:

2-carbethoxy-3-amino-4-trifluoromethyl-6-phenylfuro-<2,3-b>-pyridine

2-carbohydrazide-3-amino-4-trifluoromethyl-6-phenylfuro-<2,3-b>-pyridine