9-benzyloxy-6-[[2-(3,4-difluorophenyl)phenyl]methyl]-2-isopropyl-3,4-dihydropyrazino[1,2-c]pyrimidine-1,8-dione

Base Information

Chemical Name:9-benzyloxy-6-[[2-(3,4-difluorophenyl)phenyl]methyl]-2-isopropyl-3,4-dihydropyrazino[1,2-c]pyrimidine-1,8-dione
CAS No.:1616923-86-4
Molecular Formula:C₃₀H₂₇F₂N₃O₃
Molecular Weight:515.559
Hs Code.:

Synonyms:9-benzyloxy-6-[[2-(3,4-difluorophenyl)phenyl]methyl]-2-isopropyl-3,4-dihydropyrazino[1,2-c]pyrimidine-1,8-dione

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Chemical Property of 9-benzyloxy-6-[[2-(3,4-difluorophenyl)phenyl]methyl]-2-isopropyl-3,4-dihydropyrazino[1,2-c]pyrimidine-1,8-dione

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Technology Process of 9-benzyloxy-6-[[2-(3,4-difluorophenyl)phenyl]methyl]-2-isopropyl-3,4-dihydropyrazino[1,2-c]pyrimidine-1,8-dione

There total 10 articles about 9-benzyloxy-6-[[2-(3,4-difluorophenyl)phenyl]methyl]-2-isopropyl-3,4-dihydropyrazino[1,2-c]pyrimidine-1,8-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1616923-20-6
9-benzyloxy-6-(2-bromobenzyl)-2-isopropyl-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione

: 168267-41-2
(3,4-difluorophenyl)boronic acid

: 1616923-86-4
9-benzyloxy-6-[[2-(3,4-difluorophenyl)phenyl]methyl]-2-isopropyl-3,4-dihydropyrazino[1,2-c]pyrimidine-1,8-dione

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; toluene; at 90 ℃; for 7h; Inert atmosphere;

Reference yield:

: 1616923-19-3
5-benzyloxy-2-(2-bromobenzyl)-6-hydroxypyrimidine-4-carboxylic acid (2-hydroxyethyl)isopropylamide

: 1616923-86-4
9-benzyloxy-6-[[2-(3,4-difluorophenyl)phenyl]methyl]-2-isopropyl-3,4-dihydropyrazino[1,2-c]pyrimidine-1,8-dione

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine; diethylazodicarboxylate / dichloromethane / 2 h / 20 °C

2: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol / 7 h / 90 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; triphenylphosphine; diethylazodicarboxylate; In ethanol; dichloromethane; toluene;

Reference yield:

: 30379-55-6
benzyloxyacetic acid

: 1616923-86-4
9-benzyloxy-6-[[2-(3,4-difluorophenyl)phenyl]methyl]-2-isopropyl-3,4-dihydropyrazino[1,2-c]pyrimidine-1,8-dione

Guidance literature:: Multi-step reaction with 8 steps

1: thionyl chloride / 3 h / 0 - 20 °C

2: n-butyllithium; diisopropylamine / hexane; tetrahydrofuran / 2 h / -78 - 20 °C

3: sodium methylate / methanol / 0.25 h / 0 °C

4: water; lithium hydroxide / tetrahydrofuran / 20 °C / Reflux

5: pyridine; trichlorophosphate / 0.75 h / 0 °C

6: hydrogenchloride / tetrahydrofuran; water / 0.5 h / 20 °C

7: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 20 °C

8: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol / 7 h / 90 °C / Inert atmosphere

With pyridine; hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; thionyl chloride; di-isopropyl azodicarboxylate; water; sodium methylate; sodium carbonate; diisopropylamine; triphenylphosphine; lithium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; toluene;