9-benzyloxy-6-(2-bromobenzyl)-2-isopropyl-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione

Base Information

Chemical Name:9-benzyloxy-6-(2-bromobenzyl)-2-isopropyl-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione
CAS No.:1616923-20-6
Molecular Formula:C₂₄H₂₄BrN₃O₃
Molecular Weight:482.377
Hs Code.:

Synonyms:9-benzyloxy-6-(2-bromobenzyl)-2-isopropyl-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione

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Chemical Property of 9-benzyloxy-6-(2-bromobenzyl)-2-isopropyl-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione

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Technology Process of 9-benzyloxy-6-(2-bromobenzyl)-2-isopropyl-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione

There total 9 articles about 9-benzyloxy-6-(2-bromobenzyl)-2-isopropyl-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 1616923-19-3
5-benzyloxy-2-(2-bromobenzyl)-6-hydroxypyrimidine-4-carboxylic acid (2-hydroxyethyl)isopropylamide

: 1616923-20-6
9-benzyloxy-6-(2-bromobenzyl)-2-isopropyl-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 1616923-19-3
5-benzyloxy-2-(2-bromobenzyl)-6-oxo-3,6-dihydropyrimidine-4-carboxylic acid (2-hydroxyethyl)isopropylamide

: 1616923-20-6
9-benzyloxy-6-(2-bromobenzyl)-2-isopropyl-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In dichloromethane; at 20 ℃;

Reference yield:

: 30379-55-6
benzyloxyacetic acid

: 1616923-20-6
9-benzyloxy-6-(2-bromobenzyl)-2-isopropyl-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione

Guidance literature:: Multi-step reaction with 7 steps

1: thionyl chloride / 3 h / 0 - 20 °C

2: n-butyllithium; diisopropylamine / hexane; tetrahydrofuran / 2 h / -78 - 20 °C

3: sodium methylate / methanol / 0.25 h / 0 °C

4: water; lithium hydroxide / tetrahydrofuran / 20 °C / Reflux

5: pyridine; trichlorophosphate / 0.75 h / 0 °C

6: hydrogenchloride / tetrahydrofuran; water / 0.5 h / 20 °C

7: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 20 °C

With pyridine; hydrogenchloride; n-butyllithium; thionyl chloride; di-isopropyl azodicarboxylate; water; sodium methylate; diisopropylamine; triphenylphosphine; lithium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; hexane; dichloromethane; water;