rac-6-(3-amino-phenyl)-6-methyl-2-trifluoromethyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine

Base Information

Chemical Name:rac-6-(3-amino-phenyl)-6-methyl-2-trifluoromethyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine
CAS No.:1397683-52-1
Molecular Formula:C₁₄H₁₄F₃N₅
Molecular Weight:309.294
Hs Code.:

Synonyms:rac-6-(3-amino-phenyl)-6-methyl-2-trifluoromethyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine

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Chemical Property of rac-6-(3-amino-phenyl)-6-methyl-2-trifluoromethyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine

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Technology Process of rac-6-(3-amino-phenyl)-6-methyl-2-trifluoromethyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine

There total 1 articles about rac-6-(3-amino-phenyl)-6-methyl-2-trifluoromethyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1397683-53-2
6-methyl-6-(3-nitro-phenyl)-2-trifluoromethyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine

: 1397683-52-1
rac-6-(3-amino-phenyl)-6-methyl-2-trifluoromethyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine

Guidance literature:: With methanol; iron; ammonium chloride; In water; at 80 ℃; for 5h;

Reference yield: 55.0%

: 81719-53-1
3,5-dichloropyridine-2-carboxylic acid

: 1397683-52-1
rac-6-(3-amino-phenyl)-6-methyl-2-trifluoromethyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine

: 1397683-13-4
rac-3,5-dichloro-pyridine-2-carboxylic acid[3-(4-amino-6-methyl-2-trifluoromethyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl)-phenyl]-amide

Guidance literature:: 3,5-dichloropyridine-2-carboxylic acid; With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In methanol; at 20 ℃; for 0.0833333h;

rac-6-(3-amino-phenyl)-6-methyl-2-trifluoromethyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine; In methanol; at 0 - 20 ℃; for 4h;

With sodium carbonate; In methanol; water;

Reference yield:

: 1397683-52-1
rac-6-(3-amino-phenyl)-6-methyl-2-trifluoromethyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine

: (R*)-3,5-dichloro-pyridine-2-carboxylic acid[3-(4-amino-6-methyl-2-trifluoromethyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl)-phenyl]-amide

: (S*)-3,5-dichloro-pyridine-2-carboxylic acid[3-(4-amino-6-methyl-2-trifluoromethyl-6, 7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl)-phenyl]-amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / methanol / 0.08 h / 20 °C

1.2: 4 h / 0 - 20 °C

2.1: Chiralpak AD-H / isopropyl alcohol; carbon dioxide; isopropylamine / Resolution of racemate

With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In methanol; carbon dioxide; isopropylamine; isopropyl alcohol;