rac-3,5-dichloro-pyridine-2-carboxylic acid[3-(4-amino-6-methyl-2-trifluoromethyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl)-phenyl]-amide

Base Information

Chemical Name:rac-3,5-dichloro-pyridine-2-carboxylic acid[3-(4-amino-6-methyl-2-trifluoromethyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl)-phenyl]-amide
CAS No.:1397683-13-4
Molecular Formula:C₂₀H₁₅Cl₂F₃N₆O
Molecular Weight:483.28
Hs Code.:

Synonyms:rac-3,5-dichloro-pyridine-2-carboxylic acid[3-(4-amino-6-methyl-2-trifluoromethyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl)-phenyl]-amide

Suppliers and Price of rac-3,5-dichloro-pyridine-2-carboxylic acid[3-(4-amino-6-methyl-2-trifluoromethyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl)-phenyl]-amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of rac-3,5-dichloro-pyridine-2-carboxylic acid[3-(4-amino-6-methyl-2-trifluoromethyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl)-phenyl]-amide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of rac-3,5-dichloro-pyridine-2-carboxylic acid[3-(4-amino-6-methyl-2-trifluoromethyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl)-phenyl]-amide

There total 2 articles about rac-3,5-dichloro-pyridine-2-carboxylic acid[3-(4-amino-6-methyl-2-trifluoromethyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl)-phenyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 81719-53-1
3,5-dichloropyridine-2-carboxylic acid

: 1397683-52-1
rac-6-(3-amino-phenyl)-6-methyl-2-trifluoromethyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine

: 1397683-13-4
rac-3,5-dichloro-pyridine-2-carboxylic acid[3-(4-amino-6-methyl-2-trifluoromethyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl)-phenyl]-amide

Guidance literature:: 3,5-dichloropyridine-2-carboxylic acid; With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In methanol; at 20 ℃; for 0.0833333h;

rac-6-(3-amino-phenyl)-6-methyl-2-trifluoromethyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine; In methanol; at 0 - 20 ℃; for 4h;

With sodium carbonate; In methanol; water;

Reference yield:

: 1397683-53-2
6-methyl-6-(3-nitro-phenyl)-2-trifluoromethyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine

: 1397683-13-4
rac-3,5-dichloro-pyridine-2-carboxylic acid[3-(4-amino-6-methyl-2-trifluoromethyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl)-phenyl]-amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonium chloride; iron; methanol / water / 5 h / 80 °C

2.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / methanol / 0.08 h / 20 °C

2.2: 4 h / 0 - 20 °C

With methanol; iron; ammonium chloride; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In methanol; water;

Reference yield: 23.0%

: 1397683-13-4
rac-3,5-dichloro-pyridine-2-carboxylic acid[3-(4-amino-6-methyl-2-trifluoromethyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl)-phenyl]-amide

: (R*)-3,5-dichloro-pyridine-2-carboxylic acid[3-(4-amino-6-methyl-2-trifluoromethyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl)-phenyl]-amide

: (S*)-3,5-dichloro-pyridine-2-carboxylic acid[3-(4-amino-6-methyl-2-trifluoromethyl-6, 7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl)-phenyl]-amide

Guidance literature:: With Chiralpak AD-H; In carbon dioxide; isopropylamine; isopropyl alcohol; Purification / work up; Resolution of racemate;