((2RS,3SR)-2-methyl-3,4-diphenyl-3-propionyloxy-butyl)-carbamic acid 2,2,2-trichloro-ethyl ester

Base Information

• Chemical Name: ((2RS,3SR)-2-methyl-3,4-diphenyl-3-propionyloxy-butyl)-carbamic acid 2,2,2-trichloro-ethyl ester
• CAS No.: 63463-54-7
• Molecular Formula: C₂₃H₂₆Cl₃NO₄
• Molecular Weight: 486.823
• Mol file: 63463-54-7.mol

Synonyms:((2RS,3SR)-2-methyl-3,4-diphenyl-3-propionyloxy-butyl)-carbamic acid 2,2,2-trichloro-ethyl ester

Chemical Property of ((2RS,3SR)-2-methyl-3,4-diphenyl-3-propionyloxy-butyl)-carbamic acid 2,2,2-trichloro-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((2RS,3SR)-2-methyl-3,4-diphenyl-3-propionyloxy-butyl)-carbamic acid 2,2,2-trichloro-ethyl ester

There total 2 articles about ((2RS,3SR)-2-methyl-3,4-diphenyl-3-propionyloxy-butyl)-carbamic acid 2,2,2-trichloro-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

threo-(+/-)-4-Diphenylmethylamino-1,2-diphenyl-3-methyl-2-butanol → ((2RS,3SR)-2-methyl-3,4-diphenyl-3-propionyloxy-butyl)-carbamic acid 2,2,2-trichloro-ethyl ester (63463-54-7)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) H₂, Pd-C, EtOH, (ii) /BRN= 970619/, Et₃N, benzene

2: (i) (CF₃CO)2O, (ii) /BRN= 4010120/, Et₃N, toluene

DOI:10.1021/jm00218a015

Reference yield:

threo-(+/-)-2,2,2-Trichlorethyl-N-(3,4-diphenyl-2-methyl-3-butanol)-carbamat (63463-53-6) + propionic acid (802294-64-0,79-09-4) → ((2RS,3SR)-2-methyl-3,4-diphenyl-3-propionyloxy-butyl)-carbamic acid 2,2,2-trichloro-ethyl ester (63463-54-7)

Guidance literature:

Multistep reaction; (i) (CF₃CO)2O, (ii) /BRN= 4010120/, Et₃N, toluene;

DOI:10.1021/jm00218a015

Reference yield:

((2RS,3SR)-2-methyl-3,4-diphenyl-3-propionyloxy-butyl)-carbamic acid 2,2,2-trichloro-ethyl ester (63463-54-7) → threo-(+/-)-4-Amino-1,2-diphenyl-3-methyl-3-butanolpropionat (42576-07-8,63446-60-6,63526-60-3)

Guidance literature:

Multi-step reaction with 3 steps

1: Zn, HCO₂H / dimethylformamide

2: pentane

3: H₂ / Pd-C / ethanol; CHCl₃ / 2275.5 Torr

With formic acid; hydrogen; zinc; palladium on activated charcoal; In ethanol; chloroform; N,N-dimethyl-formamide; pentane;

DOI:10.1021/jm00218a015

upstream raw materials:

threo-(+/-)-2,2,2-Trichlorethyl-N-(3,4-diphenyl-2-methyl-3-butanol)-carbamat

propionic acid

Downstream raw materials:

6t-benzyl-2-ethyl-5r-methyl-6c-phenyl-5,6-dihydro-4H-[1,3]oxazine

threo-(+/-)-Benzyl-N-(3,4-diphenyl-2-methyl-3-butanolpropionat)-carbamat

threo-(+/-)-4-Amino-1,2-diphenyl-3-methyl-3-butanolpropionat