threo-(+/-)-2,2,2-Trichlorethyl-N-(3,4-diphenyl-2-methyl-3-butanol)-carbamat

Base Information

• Chemical Name: threo-(+/-)-2,2,2-Trichlorethyl-N-(3,4-diphenyl-2-methyl-3-butanol)-carbamat
• CAS No.: 63463-53-6
• Molecular Formula: C₂₀H₂₂Cl₃NO₃
• Molecular Weight: 430.759
• Mol file: 63463-53-6.mol

Synonyms:threo-(+/-)-2,2,2-Trichlorethyl-N-(3,4-diphenyl-2-methyl-3-butanol)-carbamat

Chemical Property of threo-(+/-)-2,2,2-Trichlorethyl-N-(3,4-diphenyl-2-methyl-3-butanol)-carbamat

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of threo-(+/-)-2,2,2-Trichlorethyl-N-(3,4-diphenyl-2-methyl-3-butanol)-carbamat

There total 1 articles about threo-(+/-)-2,2,2-Trichlorethyl-N-(3,4-diphenyl-2-methyl-3-butanol)-carbamat which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

threo-(+/-)-4-Diphenylmethylamino-1,2-diphenyl-3-methyl-2-butanol + 2,2,2-Trichloroethyl chloroformate (17341-93-4) → threo-(+/-)-2,2,2-Trichlorethyl-N-(3,4-diphenyl-2-methyl-3-butanol)-carbamat (63463-53-6)

Guidance literature:

Multistep reaction; (i) H₂, Pd-C, EtOH, (ii) /BRN= 970619/, Et₃N, benzene;

DOI:10.1021/jm00218a015

Reference yield:

threo-(+/-)-2,2,2-Trichlorethyl-N-(3,4-diphenyl-2-methyl-3-butanol)-carbamat (63463-53-6) → threo-(+/-)-4-Amino-1,2-diphenyl-3-methyl-3-butanolpropionat (42576-07-8,63446-60-6,63526-60-3)

Guidance literature:

Multi-step reaction with 4 steps

1: (i) (CF₃CO)2O, (ii) /BRN= 4010120/, Et₃N, toluene

2: Zn, HCO₂H / dimethylformamide

3: pentane

4: H₂ / Pd-C / ethanol; CHCl₃ / 2275.5 Torr

With formic acid; hydrogen; zinc; palladium on activated charcoal; In ethanol; chloroform; N,N-dimethyl-formamide; pentane;

DOI:10.1021/jm00218a015

Reference yield:

threo-(+/-)-2,2,2-Trichlorethyl-N-(3,4-diphenyl-2-methyl-3-butanol)-carbamat (63463-53-6) → threo-(+/-)-Benzyl-N-(3,4-diphenyl-2-methyl-3-butanolpropionat)-carbamat (63463-60-5,63505-82-8)

Guidance literature:

Multi-step reaction with 3 steps

1: (i) (CF₃CO)2O, (ii) /BRN= 4010120/, Et₃N, toluene

2: Zn, HCO₂H / dimethylformamide

3: pentane

With formic acid; zinc; In N,N-dimethyl-formamide; pentane;

DOI:10.1021/jm00218a015

upstream raw materials:

2,2,2-Trichloroethyl chloroformate

Downstream raw materials:

((2RS,3SR)-2-methyl-3,4-diphenyl-3-propionyloxy-butyl)-carbamic acid 2,2,2-trichloro-ethyl ester

threo-(+/-)-Benzyl-N-(3,4-diphenyl-2-methyl-3-butanolpropionat)-carbamat

threo-(+/-)-4-Amino-1,2-diphenyl-3-methyl-3-butanolpropionat

6t-benzyl-2-ethyl-5r-methyl-6c-phenyl-5,6-dihydro-4H-[1,3]oxazine