6-(2,6-difluoro-4-(4-hydroxytetrahydro-2H-pyran-4-yl)phenyl)-5-fluoropicolinic acid

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Chemical Name:6-(2,6-difluoro-4-(4-hydroxytetrahydro-2H-pyran-4-yl)phenyl)-5-fluoropicolinic acid
CAS No.:1395281-94-3
Molecular Formula:C₁₇H₁₄F₃NO₄
Molecular Weight:353.298
Hs Code.:

Synonyms:6-(2,6-difluoro-4-(4-hydroxytetrahydro-2H-pyran-4-yl)phenyl)-5-fluoropicolinic acid

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Chemical Property of 6-(2,6-difluoro-4-(4-hydroxytetrahydro-2H-pyran-4-yl)phenyl)-5-fluoropicolinic acid

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Technology Process of 6-(2,6-difluoro-4-(4-hydroxytetrahydro-2H-pyran-4-yl)phenyl)-5-fluoropicolinic acid

There total 7 articles about 6-(2,6-difluoro-4-(4-hydroxytetrahydro-2H-pyran-4-yl)phenyl)-5-fluoropicolinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1395281-94-3
6-(2,6-difluoro-4-(4-hydroxytetrahydro-2H-pyran-4-yl)phenyl)-5-fluoropicolinic acid

Guidance literature:

Reference yield:

: 374633-36-0
2-bromo-3-fluoro-6-methylpyridine

: 1395281-94-3
6-(2,6-difluoro-4-(4-hydroxytetrahydro-2H-pyran-4-yl)phenyl)-5-fluoropicolinic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium permanganate / water

2: sulfuric acid / methanol

With potassium permanganate; sulfuric acid; In methanol; water;

Reference yield:

: 461-96-1
3,5-difluorobromobenzene

: 1395281-94-3
6-(2,6-difluoro-4-(4-hydroxytetrahydro-2H-pyran-4-yl)phenyl)-5-fluoropicolinic acid

Guidance literature:: Multi-step reaction with 4 steps

1: ethyl acetate; tetrahydrofuran

2: n-butyllithium

With n-butyllithium; In tetrahydrofuran; ethyl acetate;