1-Hydroxy-1-(2-nitrophenyl)methylphosphonate 5',5'-di-O-(3'-azido-2',3'-dideoxythymidinyl) ester

Base Information

Chemical Name:1-Hydroxy-1-(2-nitrophenyl)methylphosphonate 5',5'-di-O-(3'-azido-2',3'-dideoxythymidinyl) ester
CAS No.:164652-13-5
Molecular Formula:C₂₇H₃₀N₁₁O₁₂P
Molecular Weight:731.575
Hs Code.:

Synonyms:1-Hydroxy-1-(2-nitrophenyl)methylphosphonate 5',5'-di-O-(3'-azido-2',3'-dideoxythymidinyl) ester

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Chemical Property of 1-Hydroxy-1-(2-nitrophenyl)methylphosphonate 5',5'-di-O-(3'-azido-2',3'-dideoxythymidinyl) ester

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Technology Process of 1-Hydroxy-1-(2-nitrophenyl)methylphosphonate 5',5'-di-O-(3'-azido-2',3'-dideoxythymidinyl) ester

There total 2 articles about 1-Hydroxy-1-(2-nitrophenyl)methylphosphonate 5',5'-di-O-(3'-azido-2',3'-dideoxythymidinyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 151029-28-6
5',5'-Di-O-(3'-azido-2',3'-dideoxythymidinyl) H-phosphonate diester

: 552-89-6
2-nitro-benzaldehyde

: 164652-13-5
1-Hydroxy-1-(2-nitrophenyl)methylphosphonate 5',5'-di-O-(3'-azido-2',3'-dideoxythymidinyl) ester

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 5h;

Reference yield:

: 30516-87-1,399024-19-2
3'-azido-2',3'-deoxythymidine

: 164652-13-5
1-Hydroxy-1-(2-nitrophenyl)methylphosphonate 5',5'-di-O-(3'-azido-2',3'-dideoxythymidinyl) ester

Guidance literature:: Multi-step reaction with 2 steps

1: pivaloyl chloride / tetrahydrofuran / 0.08 h / 0 °C

2: 85 percent / Et₃N / tetrahydrofuran / 5 h / 20 °C

With pivaloyl chloride; triethylamine; In tetrahydrofuran;

Reference yield:

: 164652-13-5
1-Hydroxy-1-(2-nitrophenyl)methylphosphonate 5',5'-di-O-(3'-azido-2',3'-dideoxythymidinyl) ester

: 30516-87-1,399024-19-2
3'-azido-2',3'-deoxythymidine

: 124930-59-2
3'-azido-3'-deoxythymidin-5'-yl H-phosphonate monoester

: Phosphoric acid bis-[(2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester 2-nitro-benzyl ester

Guidance literature:: With phosphate buffer; at 37 ℃; pH: 7.5; half-lives determination; also in FCS (fetal calf serum) containing RPMI (Roswell Park Memorial Institute) culture medium;