7-(2-methyl-4-oxohexanoyl)-6,8-dihydro-6-(phenylthiomethyl)pyrrolo[3,4-b]quinoline

Base Information

Chemical Name:7-(2-methyl-4-oxohexanoyl)-6,8-dihydro-6-(phenylthiomethyl)pyrrolo[3,4-b]quinoline
CAS No.:620962-76-7
Molecular Formula:C₂₅H₂₆N₂O₂S
Molecular Weight:418.56
Hs Code.:

Synonyms:7-(2-methyl-4-oxohexanoyl)-6,8-dihydro-6-(phenylthiomethyl)pyrrolo[3,4-b]quinoline

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Chemical Property of 7-(2-methyl-4-oxohexanoyl)-6,8-dihydro-6-(phenylthiomethyl)pyrrolo[3,4-b]quinoline

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Technology Process of 7-(2-methyl-4-oxohexanoyl)-6,8-dihydro-6-(phenylthiomethyl)pyrrolo[3,4-b]quinoline

There total 8 articles about 7-(2-methyl-4-oxohexanoyl)-6,8-dihydro-6-(phenylthiomethyl)pyrrolo[3,4-b]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 620962-72-3
2-methyl-4-oxohexanoyl chloride

: 3-phenylsulfanylmethyl-2,3-dihydro-1H-pyrrolo[3,4-b]quinoline

: 620962-76-7
7-(2-methyl-4-oxohexanoyl)-6,8-dihydro-6-(phenylthiomethyl)pyrrolo[3,4-b]quinoline

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 13h;
DOI:10.1021/jo030177m

Reference yield:

: 102539-95-7
2-methyl-4-oxo-hexanoic acid

: 620962-76-7
7-(2-methyl-4-oxohexanoyl)-6,8-dihydro-6-(phenylthiomethyl)pyrrolo[3,4-b]quinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / (COCl)2; pyridine / benzene / 1 h / 20 °C

2: 230 mg / Et₃N / CH₂Cl₂ / 13 h / 20 °C

With pyridine; oxalyl dichloride; triethylamine; In dichloromethane; benzene;
DOI:10.1021/jo030177m

Reference yield:

: 35740-83-1
2-bromo-3-bromomethylquinoline

: 620962-76-7
7-(2-methyl-4-oxohexanoyl)-6,8-dihydro-6-(phenylthiomethyl)pyrrolo[3,4-b]quinoline

Guidance literature:: Multi-step reaction with 6 steps

1: 91 percent / aq. NH₄OH / 120 h / 20 °C

2: 82 percent / MgSO₄ / diethyl ether / 10 h / 20 °C

3: 84 percent / Et₃N / CH₂Cl₂ / 0.5 h / 20 °C

4: 85 percent / Bu₃SnH; AIBN / benzene / 4 h / Heating

5: NaBH₄ / ethanol / 0.5 h / 20 °C

6: 230 mg / Et₃N / CH₂Cl₂ / 13 h / 20 °C

With ammonium hydroxide; sodium tetrahydroborate; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; magnesium sulfate; triethylamine; In diethyl ether; ethanol; dichloromethane; benzene;
DOI:10.1021/jo030177m