1-ethyl-7-[4-(4-{[3-ethyl-4-oxo-1,3-thiazolidin-2-ylidene]amino}-2-fluorophenyl)piperazin-1-yl]-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Base Information

Chemical Name:1-ethyl-7-[4-(4-{[3-ethyl-4-oxo-1,3-thiazolidin-2-ylidene]amino}-2-fluorophenyl)piperazin-1-yl]-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
CAS No.:1456620-70-4
Molecular Formula:C₂₇H₂₇F₂N₅O₄S
Molecular Weight:555.605
Hs Code.:

1-ethyl-7-[4-(4-{[3-ethyl-4-oxo-1,3-thiazolidin-2-ylidene]amino}-2-fluorophenyl)piperazin-1-yl]-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Synonyms:1-ethyl-7-[4-(4-{[3-ethyl-4-oxo-1,3-thiazolidin-2-ylidene]amino}-2-fluorophenyl)piperazin-1-yl]-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

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Chemical Property of 1-ethyl-7-[4-(4-{[3-ethyl-4-oxo-1,3-thiazolidin-2-ylidene]amino}-2-fluorophenyl)piperazin-1-yl]-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

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Technology Process of 1-ethyl-7-[4-(4-{[3-ethyl-4-oxo-1,3-thiazolidin-2-ylidene]amino}-2-fluorophenyl)piperazin-1-yl]-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

There total 4 articles about 1-ethyl-7-[4-(4-{[3-ethyl-4-oxo-1,3-thiazolidin-2-ylidene]amino}-2-fluorophenyl)piperazin-1-yl]-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1456620-67-9
1-ethyl-7-[4-(4-{[(ethylamino)carbonothioyl]amino}-2-fluorophenyl)piperazin-1-yl]-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

: 105-36-2
ethyl bromoacetate

: 1456620-70-4
1-ethyl-7-[4-(4-{[3-ethyl-4-oxo-1,3-thiazolidin-2-ylidene]amino}-2-fluorophenyl)piperazin-1-yl]-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Guidance literature:: 1-ethyl-7-[4-(4-{[(ethylamino)carbonothioyl]amino}-2-fluorophenyl)piperazin-1-yl]-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; With sodium acetate; acetic acid; at 20 ℃; for 0.25h;

ethyl bromoacetate; at 160 ℃; for 1h; Microwave irradiation;
DOI:10.1016/j.ejmech.2013.06.045

Reference yield:

: 70458-96-7
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid

: 1456620-70-4
1-ethyl-7-[4-(4-{[3-ethyl-4-oxo-1,3-thiazolidin-2-ylidene]amino}-2-fluorophenyl)piperazin-1-yl]-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / 0.07 h / 100 °C / Microwave irradiation

2.1: palladium on activated charcoal; hydrazine hydrate / butan-1-ol / 0.83 h / 150 °C / Microwave irradiation

3.1: ethanol / 1 h / 78 °C / Microwave irradiation

4.1: sodium acetate; acetic acid / 0.25 h / 20 °C

4.2: 1 h / 160 °C / Microwave irradiation

With palladium on activated charcoal; sodium acetate; sodium hydrogencarbonate; hydrazine hydrate; acetic acid; In ethanol; butan-1-ol;
DOI:10.1016/j.ejmech.2013.06.045

Reference yield:

: 1456620-63-5
1-ethyl-6-fluoro-7-[4-(2-fluoro-4-nitrophenyl)piperazin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

: 1456620-70-4
1-ethyl-7-[4-(4-{[3-ethyl-4-oxo-1,3-thiazolidin-2-ylidene]amino}-2-fluorophenyl)piperazin-1-yl]-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium on activated charcoal; hydrazine hydrate / butan-1-ol / 0.83 h / 150 °C / Microwave irradiation

2.1: ethanol / 1 h / 78 °C / Microwave irradiation

3.1: sodium acetate; acetic acid / 0.25 h / 20 °C

3.2: 1 h / 160 °C / Microwave irradiation

With palladium on activated charcoal; sodium acetate; hydrazine hydrate; acetic acid; In ethanol; butan-1-ol;
DOI:10.1016/j.ejmech.2013.06.045