1-<(2-amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-5-(p-carbomethoxyphenyl)-2-pentanone oxime

Base Information

Chemical Name:1-<(2-amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-5-(p-carbomethoxyphenyl)-2-pentanone oxime
CAS No.:119770-49-9
Molecular Formula:C₁₇H₂₀N₆O₆
Molecular Weight:404.382
Hs Code.:

Synonyms:1-<(2-amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-5-(p-carbomethoxyphenyl)-2-pentanone oxime

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Chemical Property of 1-<(2-amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-5-(p-carbomethoxyphenyl)-2-pentanone oxime

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Technology Process of 1-<(2-amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-5-(p-carbomethoxyphenyl)-2-pentanone oxime

There total 9 articles about 1-<(2-amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-5-(p-carbomethoxyphenyl)-2-pentanone oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1007-99-4
2-amino-6-chloro-5-nitro-3H-pyrimidine-4-one

: 119770-47-7
1-amino-5-(p-carbomethoxyphenyl)-2-pentanone oxime

: 119770-49-9
1-<(2-amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-5-(p-carbomethoxyphenyl)-2-pentanone oxime

Guidance literature:: With 2-methylmorpholine; In methanol; for 3h; Heating;
DOI:10.1021/jm00126a022

Reference yield:

: 106918-32-5
4-carbomethoxyphenylacetaldehyde

: 119770-49-9
1-<(2-amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-5-(p-carbomethoxyphenyl)-2-pentanone oxime

Guidance literature:: Multi-step reaction with 5 steps

1: 54 percent / benzene / 40 h / Heating

2: H₂ / 5percent Pd/C / ethyl acetate / 18 h / 517.1 Torr

3: 92 percent / hydroxylamine hydrochloride, pyridine / methanol / 1 h / Heating

4: 80 percent / hydrazine / methanol / 48 h

5: 75 percent / methylmorpholine / methanol / 3 h / Heating

With 2-methylmorpholine; pyridine; hydroxylamine hydrochloride; hydrogen; hydrazine; palladium on activated charcoal; In methanol; ethyl acetate; benzene;
DOI:10.1021/jm00126a022

Reference yield:

: 106918-31-4
1-methoxy-2-(4-carbomethoxyphenyl)ethylene

: 119770-49-9
1-<(2-amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-5-(p-carbomethoxyphenyl)-2-pentanone oxime

Guidance literature:: Multi-step reaction with 6 steps

1: 86 percent / H₂O, conc. H₂SO₄ / tetrahydrofuran / 11 h / Heating

2: 54 percent / benzene / 40 h / Heating

3: H₂ / 5percent Pd/C / ethyl acetate / 18 h / 517.1 Torr

4: 92 percent / hydroxylamine hydrochloride, pyridine / methanol / 1 h / Heating

5: 80 percent / hydrazine / methanol / 48 h

6: 75 percent / methylmorpholine / methanol / 3 h / Heating

With 2-methylmorpholine; pyridine; sulfuric acid; hydroxylamine hydrochloride; water; hydrogen; hydrazine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate; benzene;
DOI:10.1021/jm00126a022