Technology Process of 11-deazahomopteroic acid
There total 11 articles about 11-deazahomopteroic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 54 percent / benzene / 40 h / Heating
2: H2 / 5percent Pd/C / ethyl acetate / 18 h / 517.1 Torr
3: 92 percent / hydroxylamine hydrochloride, pyridine / methanol / 1 h / Heating
4: 80 percent / hydrazine / methanol / 48 h
5: 75 percent / methylmorpholine / methanol / 3 h / Heating
6: 1N HCl, TFA / 60 °C
With
2-methylmorpholine; pyridine; hydrogenchloride; hydroxylamine hydrochloride; hydrogen; trifluoroacetic acid; hydrazine;
palladium on activated charcoal;
In
methanol; ethyl acetate; benzene;
DOI:10.1021/jm00126a022
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 86 percent / H2O, conc. H2SO4 / tetrahydrofuran / 11 h / Heating
2: 54 percent / benzene / 40 h / Heating
3: H2 / 5percent Pd/C / ethyl acetate / 18 h / 517.1 Torr
4: 92 percent / hydroxylamine hydrochloride, pyridine / methanol / 1 h / Heating
5: 80 percent / hydrazine / methanol / 48 h
6: 75 percent / methylmorpholine / methanol / 3 h / Heating
7: 1N HCl, TFA / 60 °C
With
2-methylmorpholine; pyridine; hydrogenchloride; sulfuric acid; hydroxylamine hydrochloride; water; hydrogen; trifluoroacetic acid; hydrazine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethyl acetate; benzene;
DOI:10.1021/jm00126a022
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 1.) NaOMe / 1.) MeOH, r.t., 30 min, 2.) C6H6, a) reflux, 3 h, b) r.t., 18 h
2: 86 percent / H2O, conc. H2SO4 / tetrahydrofuran / 11 h / Heating
3: 54 percent / benzene / 40 h / Heating
4: H2 / 5percent Pd/C / ethyl acetate / 18 h / 517.1 Torr
5: 92 percent / hydroxylamine hydrochloride, pyridine / methanol / 1 h / Heating
6: 80 percent / hydrazine / methanol / 48 h
7: 75 percent / methylmorpholine / methanol / 3 h / Heating
8: 1N HCl, TFA / 60 °C
With
2-methylmorpholine; pyridine; hydrogenchloride; sulfuric acid; hydroxylamine hydrochloride; water; hydrogen; sodium methylate; trifluoroacetic acid; hydrazine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethyl acetate; benzene;
DOI:10.1021/jm00126a022
