5-Ethyl-4-[[1-(phenylmethyl)-1H-indazol-5-yl]amino]pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic Acid

Base Information

• Chemical Name: 5-Ethyl-4-[[1-(phenylmethyl)-1H-indazol-5-yl]amino]pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic Acid
• CAS No.: 310444-99-6
• Molecular Formula: C₂₃H₂₀N₆O₂
• Molecular Weight: 412.451

Synonyms:5-Ethyl-4-[[1-(phenylmethyl)-1H-indazol-5-yl]amino]pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic Acid

Chemical Property of 5-Ethyl-4-[[1-(phenylmethyl)-1H-indazol-5-yl]amino]pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic Acid

Chemical Property:

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Technology Process of 5-Ethyl-4-[[1-(phenylmethyl)-1H-indazol-5-yl]amino]pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic Acid

There total 5 articles about 5-Ethyl-4-[[1-(phenylmethyl)-1H-indazol-5-yl]amino]pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-[[1-(Phenylmethyl)-1H-indazol-5-yl]amino]-5-ethylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid ethyl ester (310443-45-9) → 5-Ethyl-4-[[1-(phenylmethyl)-1H-indazol-5-yl]amino]pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic Acid (310444-99-6)

Guidance literature:

4-[[1-(Phenylmethyl)-1H-indazol-5-yl]amino]-5-ethylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid ethyl ester; With methanol; lithium hydroxide; water; In tetrahydrofuran; at 50 ℃; for 24h;

With phosphate buffer; pH=4;

Reference yield:

ethyl 4-chloro-5-ethylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate (310442-94-5) → 5-Ethyl-4-[[1-(phenylmethyl)-1H-indazol-5-yl]amino]pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic Acid (310444-99-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / acetonitrile

2: 89 percent / aq. LiOH / tetrahydrofuran; methanol / 65 °C

With lithium hydroxide; triethylamine; In tetrahydrofuran; methanol; acetonitrile;

DOI:10.1016/j.bmcl.2005.07.027

Reference yield:

5-Ethylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one-6-carboxylic Acid Ethyl Ester (310436-60-3) → 5-Ethyl-4-[[1-(phenylmethyl)-1H-indazol-5-yl]amino]pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic Acid (310444-99-6)

Guidance literature:

Multi-step reaction with 3 steps

1: POCl₃ / 100 °C

2: Et₃N / acetonitrile

3: 89 percent / aq. LiOH / tetrahydrofuran; methanol / 65 °C

With lithium hydroxide; triethylamine; trichlorophosphate; In tetrahydrofuran; methanol; acetonitrile;

DOI:10.1016/j.bmcl.2005.07.027

upstream raw materials:

4-[[1-(Phenylmethyl)-1H-indazol-5-yl]amino]-5-ethylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid ethyl ester

ethyl 4-chloro-5-ethylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate

5-Ethylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one-6-carboxylic Acid Ethyl Ester

1-amino-3-ethyl-1H-pyrrole-2,4-dicarboxylic acid diethyl ester

Downstream raw materials:

N,5-Diethyl-4-[[1-(phenylmethyl)-1H-indazol-5-yl]amino]pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide

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