2-{[4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]methyl}-1-methylcyclopropanol

Base Information

Chemical Name:2-{[4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]methyl}-1-methylcyclopropanol
CAS No.:1221502-60-8
Molecular Formula:C₁₅H₁₆BrFN₂O
Molecular Weight:339.207
Hs Code.:

Synonyms:2-{[4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]methyl}-1-methylcyclopropanol

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Chemical Property of 2-{[4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]methyl}-1-methylcyclopropanol

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Technology Process of 2-{[4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]methyl}-1-methylcyclopropanol

There total 5 articles about 2-{[4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]methyl}-1-methylcyclopropanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 593-71-5
Chloroiodomethane

: 1221503-32-7
1-[4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]propan-2-one

: 1221502-60-8
2-{[4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]methyl}-1-methylcyclopropanol

Guidance literature:: 1-[4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]propan-2-one; With tert-butyldimethylsilyl trifluoromethanesulfonate; triethylamine; In toluene; at 0 - 20 ℃; for 15h;

Chloroiodomethane; With diethylzinc; In hexane; toluene; at 0 - 20 ℃; for 18.1667h;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 1h;

Reference yield:

: 29681-98-9
p-fluorobenzoylacetone

: 1221502-60-8
2-{[4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]methyl}-1-methylcyclopropanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; trifluoroacetic acid / isopropyl alcohol / 7 h / 80 °C

2.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 0.25 h / 0 °C

3.1: water; sodium hydroxide / methanol / 3 h / 20 °C

3.3: 12 h / 20 °C

4.1: tetrahydrofuran / 0 - 20 °C

5.1: tert-butyldimethylsilyl trifluoromethanesulfonate; triethylamine / toluene / 15 h / 0 - 20 °C

5.2: 18.17 h / 0 - 20 °C

5.3: 1 h / 0 °C

With N-Bromosuccinimide; water; tert-butyldimethylsilyl trifluoromethanesulfonate; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; isopropyl alcohol; toluene;

Reference yield:

: 1221503-30-5
ethyl [4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]acetate

: 1221502-60-8
2-{[4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]methyl}-1-methylcyclopropanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; sodium hydroxide / methanol / 3 h / 20 °C

1.3: 12 h / 20 °C

2.1: tetrahydrofuran / 0 - 20 °C

3.1: tert-butyldimethylsilyl trifluoromethanesulfonate; triethylamine / toluene / 15 h / 0 - 20 °C

3.2: 18.17 h / 0 - 20 °C

3.3: 1 h / 0 °C

With water; tert-butyldimethylsilyl trifluoromethanesulfonate; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; toluene;