2-[4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]-N-methoxy-N-methylacetamide

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Chemical Name:2-[4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]-N-methoxy-N-methylacetamide
CAS No.:1221503-31-6
Molecular Formula:C₁₄H₁₅BrFN₃O₂
Molecular Weight:356.194
Hs Code.:

Synonyms:2-[4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]-N-methoxy-N-methylacetamide

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Chemical Property of 2-[4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]-N-methoxy-N-methylacetamide

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Technology Process of 2-[4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]-N-methoxy-N-methylacetamide

There total 3 articles about 2-[4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]-N-methoxy-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1221503-30-5
ethyl [4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]acetate

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 1221503-31-6
2-[4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]-N-methoxy-N-methylacetamide

Guidance literature:: ethyl [4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]acetate; With water; sodium hydroxide; In methanol; at 20 ℃; for 3h;

With hydrogenchloride; In methanol; water;

N,O-dimethylhydroxylamine*hydrochloride; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

Reference yield:

: 29681-98-9
p-fluorobenzoylacetone

: 1221503-31-6
2-[4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]-N-methoxy-N-methylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; trifluoroacetic acid / isopropyl alcohol / 7 h / 80 °C

2.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 0.25 h / 0 °C

3.1: water; sodium hydroxide / methanol / 3 h / 20 °C

3.3: 12 h / 20 °C

With N-Bromosuccinimide; water; triethylamine; trifluoroacetic acid; sodium hydroxide; In methanol; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 403-42-9
1-(4-fluorophenyl)ethanone

: 1221503-31-6
2-[4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]-N-methoxy-N-methylacetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C

1.2: 3 h / 40 °C

2.1: triethylamine; trifluoroacetic acid / isopropyl alcohol / 7 h / 80 °C

3.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 0.25 h / 0 °C

4.1: water; sodium hydroxide / methanol / 3 h / 20 °C

4.3: 12 h / 20 °C

With N-Bromosuccinimide; water; sodium hydride; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; isopropyl alcohol;