2-tert-butyl-5-{2-fluoro-4-[6-(1-methyl-1H-pyrazol-4-yl)-2-oxo-1,2-dihydro-pyridin-4-yl]-benzyl}-4,5-dihydro-thieno[2,3-c]pyrrol-6-one

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Chemical Name:2-tert-butyl-5-{2-fluoro-4-[6-(1-methyl-1H-pyrazol-4-yl)-2-oxo-1,2-dihydro-pyridin-4-yl]-benzyl}-4,5-dihydro-thieno[2,3-c]pyrrol-6-one
CAS No.:1610472-29-1
Molecular Formula:C₂₆H₂₅FN₄O₂S
Molecular Weight:476.575
Hs Code.:

Synonyms:2-tert-butyl-5-{2-fluoro-4-[6-(1-methyl-1H-pyrazol-4-yl)-2-oxo-1,2-dihydro-pyridin-4-yl]-benzyl}-4,5-dihydro-thieno[2,3-c]pyrrol-6-one

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Chemical Property of 2-tert-butyl-5-{2-fluoro-4-[6-(1-methyl-1H-pyrazol-4-yl)-2-oxo-1,2-dihydro-pyridin-4-yl]-benzyl}-4,5-dihydro-thieno[2,3-c]pyrrol-6-one

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Technology Process of 2-tert-butyl-5-{2-fluoro-4-[6-(1-methyl-1H-pyrazol-4-yl)-2-oxo-1,2-dihydro-pyridin-4-yl]-benzyl}-4,5-dihydro-thieno[2,3-c]pyrrol-6-one

There total 13 articles about 2-tert-butyl-5-{2-fluoro-4-[6-(1-methyl-1H-pyrazol-4-yl)-2-oxo-1,2-dihydro-pyridin-4-yl]-benzyl}-4,5-dihydro-thieno[2,3-c]pyrrol-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1610472-59-7
2-tert-butyl-5-{2-fluoro-4-[2-methoxy-6-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl]benzyl}-4,5-dihydrothieno[2,3-c]pyrrol-6-one

: 1610472-29-1
2-tert-butyl-5-{2-fluoro-4-[6-(1-methyl-1H-pyrazol-4-yl)-2-oxo-1,2-dihydro-pyridin-4-yl]-benzyl}-4,5-dihydro-thieno[2,3-c]pyrrol-6-one

Guidance literature:: With chloro-trimethyl-silane; sodium iodide; In acetonitrile; at 80 ℃; for 2h;

Reference yield:

: 23806-24-8
3-methyl-2-thiophenecarboxylic acid

: 1610472-29-1
2-tert-butyl-5-{2-fluoro-4-[6-(1-methyl-1H-pyrazol-4-yl)-2-oxo-1,2-dihydro-pyridin-4-yl]-benzyl}-4,5-dihydro-thieno[2,3-c]pyrrol-6-one

Guidance literature:: Multi-step reaction with 7 steps

1: sulfuric acid / 72 h / 0 - 20 °C

2: aluminum (III) chloride / dichloromethane / -78 - 20 °C / Inert atmosphere

3: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 90 °C

4: caesium carbonate / acetonitrile / 20 °C

5: lithium hydroxide monohydrate / water; tetrahydrofuran / 18 h / 60 °C

6: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

7: chloro-trimethyl-silane; sodium iodide / acetonitrile / 2 h / 80 °C

With aluminum (III) chloride; N-Bromosuccinimide; chloro-trimethyl-silane; lithium hydroxide monohydrate; 2,2'-azobis(isobutyronitrile); sulfuric acid; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; caesium carbonate; N-ethyl-N,N-diisopropylamine; sodium iodide; In tetrahydrofuran; tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1361386-45-9
5-tert-butyl-3-methylthiophene-2-carboxylic acid methyl ester

: 1610472-29-1
2-tert-butyl-5-{2-fluoro-4-[6-(1-methyl-1H-pyrazol-4-yl)-2-oxo-1,2-dihydro-pyridin-4-yl]-benzyl}-4,5-dihydro-thieno[2,3-c]pyrrol-6-one

Guidance literature:: Multi-step reaction with 5 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 90 °C

2: caesium carbonate / acetonitrile / 20 °C

3: lithium hydroxide monohydrate / water; tetrahydrofuran / 18 h / 60 °C

4: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

5: chloro-trimethyl-silane; sodium iodide / acetonitrile / 2 h / 80 °C

With N-Bromosuccinimide; chloro-trimethyl-silane; lithium hydroxide monohydrate; 2,2'-azobis(isobutyronitrile); benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; caesium carbonate; N-ethyl-N,N-diisopropylamine; sodium iodide; In tetrahydrofuran; tetrachloromethane; water; N,N-dimethyl-formamide; acetonitrile;