Technology Process of benzyl (1S,2S)-1-[2-oxo-2-(piperidin-1-yl)ethylcarbamoyl]-2-methylbutylcarbamate
There total 3 articles about benzyl (1S,2S)-1-[2-oxo-2-(piperidin-1-yl)ethylcarbamoyl]-2-methylbutylcarbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
N-Cbz-L-Isoleucine;
With
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 0 ℃;
for 0.25h;
Inert atmosphere;
2-amino-1-(piperidin-1-yl)ethan-1-one;
In
dichloromethane;
at 0 ℃;
for 0.166667h;
Inert atmosphere;
DOI:10.1039/c0ob00628a
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 0 °C / Inert atmosphere
1.2: 0.17 h / 0 °C / Inert atmosphere
2.1: palladium 10% on activated carbon; hydrogen / methanol / Inert atmosphere
3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 0 °C / Inert atmosphere
3.2: 0.17 h / 0 °C / Inert atmosphere
With
palladium 10% on activated carbon; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine;
In
methanol; dichloromethane;
DOI:10.1039/c0ob00628a
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: palladium 10% on activated carbon; hydrogen / methanol / Inert atmosphere
2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 0 °C / Inert atmosphere
2.2: 0.17 h / 0 °C / Inert atmosphere
With
palladium 10% on activated carbon; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine;
In
methanol; dichloromethane;
DOI:10.1039/c0ob00628a