benzyl (1S,2S)-1-[2-oxo-2-(piperidin-1-yl)ethylcarbamoyl]-2-methylbutylcarbamate

Base Information

Chemical Name:benzyl (1S,2S)-1-[2-oxo-2-(piperidin-1-yl)ethylcarbamoyl]-2-methylbutylcarbamate
CAS No.:1273502-58-1
Molecular Formula:C₂₁H₃₁N₃O₄
Molecular Weight:389.495
Hs Code.:

Synonyms:benzyl (1S,2S)-1-[2-oxo-2-(piperidin-1-yl)ethylcarbamoyl]-2-methylbutylcarbamate

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Chemical Property of benzyl (1S,2S)-1-[2-oxo-2-(piperidin-1-yl)ethylcarbamoyl]-2-methylbutylcarbamate

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Technology Process of benzyl (1S,2S)-1-[2-oxo-2-(piperidin-1-yl)ethylcarbamoyl]-2-methylbutylcarbamate

There total 3 articles about benzyl (1S,2S)-1-[2-oxo-2-(piperidin-1-yl)ethylcarbamoyl]-2-methylbutylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 3160-59-6
N-Cbz-L-Isoleucine

: 5649-08-1
2-amino-1-(piperidin-1-yl)ethan-1-one

: 1273502-58-1
benzyl (1S,2S)-1-[2-oxo-2-(piperidin-1-yl)ethylcarbamoyl]-2-methylbutylcarbamate

Guidance literature:: N-Cbz-L-Isoleucine; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 0.25h; Inert atmosphere;

2-amino-1-(piperidin-1-yl)ethan-1-one; In dichloromethane; at 0 ℃; for 0.166667h; Inert atmosphere;
DOI:10.1039/c0ob00628a

Reference yield:

: 110-89-4
piperidine

: 1273502-58-1
benzyl (1S,2S)-1-[2-oxo-2-(piperidin-1-yl)ethylcarbamoyl]-2-methylbutylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 0 °C / Inert atmosphere

1.2: 0.17 h / 0 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / methanol / Inert atmosphere

3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 0 °C / Inert atmosphere

3.2: 0.17 h / 0 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;
DOI:10.1039/c0ob00628a

Reference yield:

: 3886-37-1
2-oxo-2-(piperidin-1-yl)ethyl-carbamic acid benzyl ester

: 1273502-58-1
benzyl (1S,2S)-1-[2-oxo-2-(piperidin-1-yl)ethylcarbamoyl]-2-methylbutylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol / Inert atmosphere

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 0 °C / Inert atmosphere

2.2: 0.17 h / 0 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;
DOI:10.1039/c0ob00628a