(R)-2-Benzyloxycarbonylamino-4,4-dicarboxy-5-morpholin-4-yl-pentanoic acid methyl ester; compound with trifluoro-acetic acid

Base Information

Chemical Name:(R)-2-Benzyloxycarbonylamino-4,4-dicarboxy-5-morpholin-4-yl-pentanoic acid methyl ester; compound with trifluoro-acetic acid
CAS No.:80954-44-5
Molecular Formula:C₂HF₃O₂*C₂₀H₂₆N₂O₉
Molecular Weight:552.458
Hs Code.:

Synonyms:(R)-2-Benzyloxycarbonylamino-4,4-dicarboxy-5-morpholin-4-yl-pentanoic acid methyl ester; compound with trifluoro-acetic acid

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Chemical Property of (R)-2-Benzyloxycarbonylamino-4,4-dicarboxy-5-morpholin-4-yl-pentanoic acid methyl ester; compound with trifluoro-acetic acid

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Technology Process of (R)-2-Benzyloxycarbonylamino-4,4-dicarboxy-5-morpholin-4-yl-pentanoic acid methyl ester; compound with trifluoro-acetic acid

There total 2 articles about (R)-2-Benzyloxycarbonylamino-4,4-dicarboxy-5-morpholin-4-yl-pentanoic acid methyl ester; compound with trifluoro-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 110-91-8,99108-56-2
morpholine

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 80954-39-8
N-(benzyloxycarbonyl)-D-γ-carboxyglutamic acid α-methyl ester

: 76-05-1
trifluoroacetic acid

: 80954-44-5
(R)-2-Benzyloxycarbonylamino-4,4-dicarboxy-5-morpholin-4-yl-pentanoic acid methyl ester; compound with trifluoro-acetic acid

Guidance literature:: In water; for 1h; pH 4.5;
DOI:10.1021/jo00349a003

Reference yield:

: 66513-60-8
N-(benzyloxycarbonyl)-γ,γ-di-tert-butyl-D-γ-carboxyglutamic acid α-methyl ester

: 80954-44-5
(R)-2-Benzyloxycarbonylamino-4,4-dicarboxy-5-morpholin-4-yl-pentanoic acid methyl ester; compound with trifluoro-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / aq. TFA / 2 h / Ambient temperature

2: 83 percent / H₂O / 1 h / pH 4.5

With trifluoroacetic acid; In water;
DOI:10.1021/jo00349a003