4-(4-(4-(2-hydroxyethyl)piperazine-1-carbonyl)phenyl)-1-methyl-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde

Base Information

• Chemical Name: 4-(4-(4-(2-hydroxyethyl)piperazine-1-carbonyl)phenyl)-1-methyl-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde
• CAS No.: 1198278-03-3
• Molecular Formula: C₂₂H₂₄N₄O₃
• Molecular Weight: 392.458

Synonyms:4-(4-(4-(2-hydroxyethyl)piperazine-1-carbonyl)phenyl)-1-methyl-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde

Chemical Property of 4-(4-(4-(2-hydroxyethyl)piperazine-1-carbonyl)phenyl)-1-methyl-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde

Chemical Property:

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Technology Process of 4-(4-(4-(2-hydroxyethyl)piperazine-1-carbonyl)phenyl)-1-methyl-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde

There total 1 articles about 4-(4-(4-(2-hydroxyethyl)piperazine-1-carbonyl)phenyl)-1-methyl-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromo-1-methyl-1-H-pyrrolo[2,3-b]pyridine-3-carbaldehyde (1198277-84-7) + (4-{[4-(2-hydroxyethyl)piperazin-1-yl]carbonyl}phenyl)boronic acid (913943-06-3) → 4-(4-(4-(2-hydroxyethyl)piperazine-1-carbonyl)phenyl)-1-methyl-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde (1198278-03-3)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; Heating;

DOI:10.1016/j.bmcl.2010.01.135

Reference yield: 72.0%

4-hydroxy-1-benzofuran-3(2H)-one (19278-81-0) + 4-(4-(4-(2-hydroxyethyl)piperazine-1-carbonyl)phenyl)-1-methyl-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde (1198278-03-3) → (2Z)-4-hydroxy-2-{[4-(4-{[4-(2-hydroxyethyl)piperazin-1-yl]carbonyl}phenyl)-1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl]methylidene}-1-benzofuran-3(2H)-one (1198276-03-7)

Guidance literature:

hydrogenchloride; In ethanol; water; at 80 ℃; for 5.2h;

upstream raw materials:

4-bromo-1-methyl-1-H-pyrrolo[2,3-b]pyridine-3-carbaldehyde

(4-{[4-(2-hydroxyethyl)piperazin-1-yl]carbonyl}phenyl)boronic acid

Downstream raw materials:

(2Z)-4-hydroxy-2-{[4-(4-{[4-(2-hydroxyethyl)piperazin-1-yl]carbonyl}phenyl)-1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl]methylidene}-1-benzofuran-3(2H)-one

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