3-((4-methoxy-2-(4-methylpiperazin-1-yl)pyrimidin-5-yl)thio)-aniline

Base Information

• Chemical Name: 3-((4-methoxy-2-(4-methylpiperazin-1-yl)pyrimidin-5-yl)thio)-aniline
• CAS No.: 1567950-42-8
• Molecular Formula: C₁₆H₂₁N₅OS
• Molecular Weight: 331.442
• Mol file: 1567950-42-8.mol

Synonyms:3-((4-methoxy-2-(4-methylpiperazin-1-yl)pyrimidin-5-yl)thio)-aniline

Chemical Property of 3-((4-methoxy-2-(4-methylpiperazin-1-yl)pyrimidin-5-yl)thio)-aniline

Chemical Property:

Purity/Quality:

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Technology Process of 3-((4-methoxy-2-(4-methylpiperazin-1-yl)pyrimidin-5-yl)thio)-aniline

There total 1 articles about 3-((4-methoxy-2-(4-methylpiperazin-1-yl)pyrimidin-5-yl)thio)-aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

3-aminothiophenol (22948-02-3) + 5-iodo-4-methoxy-2-(4-methylpiperazin-1-yl)pyrimidine (1567950-38-2) → 3-((4-methoxy-2-(4-methylpiperazin-1-yl)pyrimidin-5-yl)thio)-aniline (1567950-42-8)

Guidance literature:

With copper(l) iodide; 2.9-dimethyl-1,10-phenanthroline; potassium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 24h; Inert atmosphere;

DOI:10.1021/jm401552y

Reference yield:

BOC-glycine (4530-20-5) + 3-((4-methoxy-2-(4-methylpiperazin-1-yl)pyrimidin-5-yl)thio)-aniline (1567950-42-8) → C23H32N6O4S

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 5h; Inert atmosphere;

DOI:10.1021/jm401552y

Reference yield:

3-((4-methoxy-2-(4-methylpiperazin-1-yl)pyrimidin-5-yl)thio)-aniline (1567950-42-8) → 2-amino-N-(3-((4-methoxy-2-(4-methylpiperazin-1-yl)pyrimidin-5-yl)thio)phenyl)acetamide (1567950-59-7)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 5 h / 20 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere

With triethylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/jm401552y

upstream raw materials:

3-aminothiophenol

5-iodo-4-methoxy-2-(4-methylpiperazin-1-yl)pyrimidine

Downstream raw materials:

2-amino-N-(3-((4-methoxy-2-(4-methylpiperazin-1-yl)pyrimidin-5-yl)thio)phenyl)acetamide