(S)-1-{(S)-2-amino-3-[4-(1-(thiophen-2-ylmethyl)-1H-1,2,3-triazol-4-yl)phenyl]propanoyl}pyrrolidine-2-carbonitrile hydrochloride

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Chemical Name:(S)-1-{(S)-2-amino-3-[4-(1-(thiophen-2-ylmethyl)-1H-1,2,3-triazol-4-yl)phenyl]propanoyl}pyrrolidine-2-carbonitrile hydrochloride
CAS No.:1429503-51-4
Molecular Formula:C₂₁H₂₂N₆OS*ClH
Molecular Weight:442.972
Hs Code.:

Synonyms:(S)-1-{(S)-2-amino-3-[4-(1-(thiophen-2-ylmethyl)-1H-1,2,3-triazol-4-yl)phenyl]propanoyl}pyrrolidine-2-carbonitrile hydrochloride

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Chemical Property of (S)-1-{(S)-2-amino-3-[4-(1-(thiophen-2-ylmethyl)-1H-1,2,3-triazol-4-yl)phenyl]propanoyl}pyrrolidine-2-carbonitrile hydrochloride

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Technology Process of (S)-1-{(S)-2-amino-3-[4-(1-(thiophen-2-ylmethyl)-1H-1,2,3-triazol-4-yl)phenyl]propanoyl}pyrrolidine-2-carbonitrile hydrochloride

There total 4 articles about (S)-1-{(S)-2-amino-3-[4-(1-(thiophen-2-ylmethyl)-1H-1,2,3-triazol-4-yl)phenyl]propanoyl}pyrrolidine-2-carbonitrile hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1429503-91-2
tert-butyl {(S)-1-[(S)-2-cyanopyrrolidin-1-yl]-1-oxo-3-[4-(1-(thiophen-2-ylmethyl)-1H-1,2,3-triazol-4-yl)phenyl]propan-2-yl}carbamate

: 1429503-51-4
(S)-1-{(S)-2-amino-3-[4-(1-(thiophen-2-ylmethyl)-1H-1,2,3-triazol-4-yl)phenyl]propanoyl}pyrrolidine-2-carbonitrile hydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether; dichloromethane; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.bmc.2013.07.034

Reference yield:

: 680227-80-9
[(S)-2-((S)-2-Cyano-pyrrolidin-1-yl)-1-(4-iodo-benzyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

: 1429503-51-4
(S)-1-{(S)-2-amino-3-[4-(1-(thiophen-2-ylmethyl)-1H-1,2,3-triazol-4-yl)phenyl]propanoyl}pyrrolidine-2-carbonitrile hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 20 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

3: copper(ll) sulfate pentahydrate; sodium L-ascorbate / ethanol / 3 h / 20 °C

4: hydrogenchloride / dichloromethane; diethyl ether / 2 h / 20 °C / Inert atmosphere

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; copper(ll) sulfate pentahydrate; tetrabutyl ammonium fluoride; sodium L-ascorbate; triethylamine; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; 1: |Sonogashira Cross-Coupling;
DOI:10.1016/j.bmc.2013.07.034

Reference yield:

: 1429503-68-3
C₂₄H₃₃N₃O₃Si

: 1429503-51-4
(S)-1-{(S)-2-amino-3-[4-(1-(thiophen-2-ylmethyl)-1H-1,2,3-triazol-4-yl)phenyl]propanoyl}pyrrolidine-2-carbonitrile hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

2: copper(ll) sulfate pentahydrate; sodium L-ascorbate / ethanol / 3 h / 20 °C

3: hydrogenchloride / dichloromethane; diethyl ether / 2 h / 20 °C / Inert atmosphere

With hydrogenchloride; copper(ll) sulfate pentahydrate; tetrabutyl ammonium fluoride; sodium L-ascorbate; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane;
DOI:10.1016/j.bmc.2013.07.034