N-(2-Acetyl-5-hydroxy-5-methyl-3-oxo-2-cyclohexenyl)-glycinethylester

Base Information

• Chemical Name: N-(2-Acetyl-5-hydroxy-5-methyl-3-oxo-2-cyclohexenyl)-glycinethylester
• CAS No.: 97066-01-8
• Molecular Formula: C₁₃H₁₉NO₅
• Molecular Weight: 269.298
• Mol file: 97066-01-8.mol

Synonyms:N-(2-Acetyl-5-hydroxy-5-methyl-3-oxo-2-cyclohexenyl)-glycinethylester

Chemical Property of N-(2-Acetyl-5-hydroxy-5-methyl-3-oxo-2-cyclohexenyl)-glycinethylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-Acetyl-5-hydroxy-5-methyl-3-oxo-2-cyclohexenyl)-glycinethylester

There total 2 articles about N-(2-Acetyl-5-hydroxy-5-methyl-3-oxo-2-cyclohexenyl)-glycinethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

glycine ethyl ester hydrochloride (623-33-6) + 2-Acetyl-3-dimethylamino-5-hydroxy-5-methyl-2-cyclohexenon (97066-60-9) → N-(2-Acetyl-5-hydroxy-5-methyl-3-oxo-2-cyclohexenyl)-glycinethylester (97066-01-8)

Guidance literature:

With ammonia; 1.) CH₂Cl₂, 2.) ethanol, reflux, 2 h;

DOI:10.1002/ardp.19853180408

Reference yield:

3-acetyl-2,6-dimethyl-4H-pyran-4-one (7521-38-2) → N-(2-Acetyl-5-hydroxy-5-methyl-3-oxo-2-cyclohexenyl)-glycinethylester (97066-01-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / ethanol / 0.25 h / Ambient temperature

2: 52 percent / 1.) NH₃ / 1.) CH₂Cl₂, 2.) ethanol, reflux, 2 h

With ammonia; In ethanol;

DOI:10.1002/ardp.19853180408

Reference yield: 42.0%

N-(2-Acetyl-5-hydroxy-5-methyl-3-oxo-2-cyclohexenyl)-glycinethylester (97066-01-8) → N-(2-Acetyl-3-hydroxy-5-methyl-phenyl)-glycinethylester

Guidance literature:

With potassium hydroxide; In ethanol; at 40 ℃; for 0.5h;

DOI:10.1002/ardp.19853180408

upstream raw materials:

glycine ethyl ester hydrochloride

2-Acetyl-3-dimethylamino-5-hydroxy-5-methyl-2-cyclohexenon

3-acetyl-2,6-dimethyl-4H-pyran-4-one