3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylbenzaldehyde

Base Information

Chemical Name:3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylbenzaldehyde
CAS No.:1334608-09-1
Molecular Formula:C₂₂H₂₁ClN₂O₂
Molecular Weight:380.874
Hs Code.:

Synonyms:3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylbenzaldehyde

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Chemical Property of 3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylbenzaldehyde

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Technology Process of 3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylbenzaldehyde

There total 2 articles about 3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylbenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 480438-56-0
{3-chloro-4-[(1-methylethyl)oxy]phenyl}boronic acid

: 1334607-96-3
3-(2-chloro-5-pyrimidinyl)-2-ethylbenzaldehyde

: 1334608-09-1
3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylbenzaldehyde

Guidance literature:: With caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 120 ℃; for 0.25h; Inert atmosphere; Sealed; Biotage Initiator;

Reference yield:

: 1260023-43-5
2-ethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde

: 1334608-09-1
3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylbenzaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 2 h / 120 °C / Inert atmosphere

2: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.25 h / 120 °C / Inert atmosphere; Sealed; Biotage Initiator

With potassium phosphate; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water;

Reference yield:

: 13200-60-7
Sarcosine ethyl ester

: 1334608-09-1
3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylbenzaldehyde

: 1334608-24-0
ethyl N-{[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]methyl}-N-methylglycinate

Guidance literature:: Sarcosine ethyl ester; 3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylbenzaldehyde; With sodium acetate; acetic acid; In dichloromethane; at 20 ℃; for 15h;

With sodium tris(acetoxy)borohydride; In dichloromethane; for 2h;