ethyl N-{[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]methyl}-N-methylglycinate

Base Information

Chemical Name:ethyl N-{[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]methyl}-N-methylglycinate
CAS No.:1334608-24-0
Molecular Formula:C₂₇H₃₂ClN₃O₃
Molecular Weight:482.022
Hs Code.:

Synonyms:ethyl N-{[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]methyl}-N-methylglycinate

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Chemical Property of ethyl N-{[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]methyl}-N-methylglycinate

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Technology Process of ethyl N-{[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]methyl}-N-methylglycinate

There total 3 articles about ethyl N-{[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]methyl}-N-methylglycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13200-60-7
Sarcosine ethyl ester

: 1334608-09-1
3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylbenzaldehyde

: 1334608-24-0
ethyl N-{[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]methyl}-N-methylglycinate

Guidance literature:: Sarcosine ethyl ester; 3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylbenzaldehyde; With sodium acetate; acetic acid; In dichloromethane; at 20 ℃; for 15h;

With sodium tris(acetoxy)borohydride; In dichloromethane; for 2h;

Reference yield:

: 1260023-43-5
2-ethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde

: 1334608-24-0
ethyl N-{[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]methyl}-N-methylglycinate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 2 h / 120 °C / Inert atmosphere

2.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.25 h / 120 °C / Inert atmosphere; Sealed; Biotage Initiator

3.1: sodium acetate; acetic acid / dichloromethane / 15 h / 20 °C

3.2: 2 h

With potassium phosphate; sodium acetate; caesium carbonate; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; dichloromethane; water;

Reference yield:

: 1334607-96-3
3-(2-chloro-5-pyrimidinyl)-2-ethylbenzaldehyde

: 1334608-24-0
ethyl N-{[3-(2-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]methyl}-N-methylglycinate

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.25 h / 120 °C / Inert atmosphere; Sealed; Biotage Initiator

2.1: sodium acetate; acetic acid / dichloromethane / 15 h / 20 °C

2.2: 2 h

With sodium acetate; caesium carbonate; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; dichloromethane; water;