4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-furan-3-yl]-N-(1,1-dioxo-1λ⁶-thietan-3-yl)-2-methyl-benzamide

Base Information

• Chemical Name: 4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-furan-3-yl]-N-(1,1-dioxo-1λ⁶-thietan-3-yl)-2-methyl-benzamide
• CAS No.: 1331886-51-1
• Molecular Formula: C₂₂H₁₈Cl₂F₃NO₄S
• Molecular Weight: 520.356

Synonyms:4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-furan-3-yl]-N-(1,1-dioxo-1λ⁶-thietan-3-yl)-2-methyl-benzamide

Chemical Property of 4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-furan-3-yl]-N-(1,1-dioxo-1λ⁶-thietan-3-yl)-2-methyl-benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-furan-3-yl]-N-(1,1-dioxo-1λ⁶-thietan-3-yl)-2-methyl-benzamide

There total 12 articles about 4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-furan-3-yl]-N-(1,1-dioxo-1λ⁶-thietan-3-yl)-2-methyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-furan-3-yl]-2-methyl-benzoic acid (1331886-83-9) + 1,1-dioxothietan-3-ylamine trifluoroacetate → 4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-furan-3-yl]-N-(1,1-dioxo-1λ6-thietan-3-yl)-2-methyl-benzamide (1331886-51-1)

Guidance literature:

4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-furan-3-yl]-2-methyl-benzoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 18h;

1,1-dioxothietan-3-ylamine trifluoroacetate; With triethylamine; In dichloromethane; at 20 ℃; for 5h;

Reference yield:

(1,1-dioxo-1λ6-thietan-3-yl)amine trifluoroacetate (1331887-01-4) + C19H12Cl3F3O2 → 4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-furan-3-yl]-N-(1,1-dioxo-1λ6-thietan-3-yl)-2-methyl-benzamide (1331886-51-1)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 5h;

Reference yield:

4-bromo-2-methylbenzoic acid (68837-59-2) → 4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-furan-3-yl]-N-(1,1-dioxo-1λ6-thietan-3-yl)-2-methyl-benzamide (1331886-51-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 3 h / 20 °C

1.2: 0.5 h / 2 - 20 °C

2.1: n-butyllithium / tetrahydrofuran / 0.42 h / -100 °C / Inert atmosphere

2.2: 1 h / -100 °C

3.1: thionyl chloride; n-butyllithium / dichloromethane / -78 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 6 h / 20 °C

5.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 18 h / 20 °C

5.2: 5 h / 20 °C

With n-butyllithium; thionyl chloride; oxalyl dichloride; trifluoroacetic acid; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;

upstream raw materials:

4-bromo-2-methylbenzoic acid

4-bromo-2-methyl-benzoic acid tert-butyl ester

3,5-dichloro-2,2,2-trifluoroacetophenone

2-(3,5-dichloro-phenyl)-1,1,1-trifluoro-pent-4-yn-2-ol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1331886-51-1 4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-furan-3-yl]-N-(1,1-dioxo-1λ⁶-thietan-3-yl)-2-methyl-benzamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send