4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-furan-3-yl]-2-methyl-benzoic acid

Base Information

Chemical Name:4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-furan-3-yl]-2-methyl-benzoic acid
CAS No.:1331886-83-9
Molecular Formula:C₁₉H₁₃Cl₂F₃O₃
Molecular Weight:417.212
Hs Code.:

Synonyms:4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-furan-3-yl]-2-methyl-benzoic acid

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Chemical Property of 4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-furan-3-yl]-2-methyl-benzoic acid

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Technology Process of 4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-furan-3-yl]-2-methyl-benzoic acid

There total 10 articles about 4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-furan-3-yl]-2-methyl-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: tert-butyl 4-[5-(3,5-dichlorophenyl)-2-hydroxy-5-(trifluoromethyl)tetrahydrofuran-3-yl]-2-methylbenzoate

: 1331886-83-9
4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-furan-3-yl]-2-methyl-benzoic acid

Guidance literature:: With toluene-4-sulfonic acid; In 5,5-dimethyl-1,3-cyclohexadiene; at 130 ℃; for 1.5h; Inert atmosphere;

Reference yield:

: 130336-16-2
3,5-dichloro-2,2,2-trifluoroacetophenone

: 1331886-83-9
4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-furan-3-yl]-2-methyl-benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: diisopropylamine; n-butyllithium / tetrahydrofuran / 90 h / -20 °C

1.2: 2.5 h / -78 - 20 °C

2.1: 5-bromo-1-oxy-nicotinic acid methyl ester; bis(trifluoromethanesulfonyl)amide / [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold(I) / 1,2-dichloro-ethane / 20 °C / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran / 0.42 h / -100 °C / Inert atmosphere

3.2: 1 h / -100 °C

4.1: thionyl chloride; n-butyllithium / dichloromethane / -78 °C / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane / 6 h / 20 °C

With n-butyllithium; thionyl chloride; bis(trifluoromethanesulfonyl)amide; diisopropylamine; trifluoroacetic acid; 5-bromo-1-oxy-nicotinic acid methyl ester; [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold(I); In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;

Reference yield:

: 68837-59-2
4-bromo-2-methylbenzoic acid

: 1331886-83-9
4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-furan-3-yl]-2-methyl-benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 3 h / 20 °C

1.2: 0.5 h / 2 - 20 °C

2.1: n-butyllithium / tetrahydrofuran / 0.42 h / -100 °C / Inert atmosphere

2.2: 1 h / -100 °C

3.1: thionyl chloride; n-butyllithium / dichloromethane / -78 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 6 h / 20 °C

With n-butyllithium; thionyl chloride; oxalyl dichloride; trifluoroacetic acid; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;