(2R)-4-{5-fluoro-2-oxo-4-[4-(2H-1,2,3-triazol-2-yl)phenyl]pyridin-1(2H)-yl}-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide

Base Information

Chemical Name:(2R)-4-{5-fluoro-2-oxo-4-[4-(2H-1,2,3-triazol-2-yl)phenyl]pyridin-1(2H)-yl}-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide
CAS No.:1398501-95-5
Molecular Formula:C₁₉H₂₀FN₅O₅S
Molecular Weight:449.463
Hs Code.:

Synonyms:(2R)-4-{5-fluoro-2-oxo-4-[4-(2H-1,2,3-triazol-2-yl)phenyl]pyridin-1(2H)-yl}-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide

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Chemical Property of (2R)-4-{5-fluoro-2-oxo-4-[4-(2H-1,2,3-triazol-2-yl)phenyl]pyridin-1(2H)-yl}-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide

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Technology Process of (2R)-4-{5-fluoro-2-oxo-4-[4-(2H-1,2,3-triazol-2-yl)phenyl]pyridin-1(2H)-yl}-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide

There total 10 articles about (2R)-4-{5-fluoro-2-oxo-4-[4-(2H-1,2,3-triazol-2-yl)phenyl]pyridin-1(2H)-yl}-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.5%

: 1398503-39-3
(2R)-4-{5-fluoro-2-oxo-4-[4-(2H-1,2,3-triazol-2-yl)phenyl]pyridin-1(2H)-yl}-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

: 1398501-95-5
(2R)-4-{5-fluoro-2-oxo-4-[4-(2H-1,2,3-triazol-2-yl)phenyl]pyridin-1(2H)-yl}-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide

Guidance literature:: With pyridinium p-toluenesulfonate; In ethanol; at 70 ℃; for 3h;

Reference yield:

: 1017793-20-2
preparation of 2,5-difluoro-4-iodopyridine

: 1398501-95-5
(2R)-4-{5-fluoro-2-oxo-4-[4-(2H-1,2,3-triazol-2-yl)phenyl]pyridin-1(2H)-yl}-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride; water / 1,4-dioxane / Reflux

2.1: caesium carbonate / tetrahydrofuran / 70 °C / Reflux

3.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 2-methyltetrahydrofuran / 60 °C

4.1: potassium hydroxide / water; 2-methyltetrahydrofuran / 20 °C

5.1: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine / 2-methyltetrahydrofuran / 1 h / 20 °C

5.2: 20 °C

6.1: pyridinium p-toluenesulfonate / ethanol / 3 h / 70 °C

With 4-methyl-morpholine; hydrogenchloride; potassium phosphate; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; water; pyridinium p-toluenesulfonate; caesium carbonate; potassium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 2-methyltetrahydrofuran; 1,4-dioxane; ethanol; water;

Reference yield:

: 1312478-47-9
ethyl (±)-4-bromo-2-methyl-2-(methylsulfonyl)butanoate

: 1398501-95-5
(2R)-4-{5-fluoro-2-oxo-4-[4-(2H-1,2,3-triazol-2-yl)phenyl]pyridin-1(2H)-yl}-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: ChiralPak AD / ethanol / Resolution of racemate

2.1: caesium carbonate / tetrahydrofuran / 70 °C / Reflux

3.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 2-methyltetrahydrofuran / 60 °C

4.1: potassium hydroxide / water; 2-methyltetrahydrofuran / 20 °C

5.1: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine / 2-methyltetrahydrofuran / 1 h / 20 °C

5.2: 20 °C

6.1: pyridinium p-toluenesulfonate / ethanol / 3 h / 70 °C

With 4-methyl-morpholine; potassium phosphate; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; pyridinium p-toluenesulfonate; caesium carbonate; potassium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 2-methyltetrahydrofuran; ethanol; water;