(R)-2-(2,4-dimethoxy-5-nitropyrimidin-6-yl)-2-(2,3-O-isopropylidene-5-O-(triphenylmethyl)-α-D-ribofuranosyl)acetonitrile

Base Information

• Chemical Name: (R)-2-(2,4-dimethoxy-5-nitropyrimidin-6-yl)-2-(2,3-O-isopropylidene-5-O-(triphenylmethyl)-α-D-ribofuranosyl)acetonitrile
• CAS No.: 99232-86-7
• Molecular Formula: C₃₅H₃₄N₄O₈
• Molecular Weight: 638.677
• Mol file: 99232-86-7.mol

Synonyms:(R)-2-(2,4-dimethoxy-5-nitropyrimidin-6-yl)-2-(2,3-O-isopropylidene-5-O-(triphenylmethyl)-α-D-ribofuranosyl)acetonitrile

Chemical Property of (R)-2-(2,4-dimethoxy-5-nitropyrimidin-6-yl)-2-(2,3-O-isopropylidene-5-O-(triphenylmethyl)-α-D-ribofuranosyl)acetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-(2,4-dimethoxy-5-nitropyrimidin-6-yl)-2-(2,3-O-isopropylidene-5-O-(triphenylmethyl)-α-D-ribofuranosyl)acetonitrile

There total 1 articles about (R)-2-(2,4-dimethoxy-5-nitropyrimidin-6-yl)-2-(2,3-O-isopropylidene-5-O-(triphenylmethyl)-α-D-ribofuranosyl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-cyanomethyl-2,6-dimethoxy-5-nitropyrimidine (84538-44-3) + 2,3-O-Isopropylidene-5-O-trityl-α,β-ribofuranosyl chloride (58166-67-9) → (R)-2-(2,4-dimethoxy-5-nitropyrimidin-6-yl)-2-(2,3-O-isopropylidene-5-O-(triphenylmethyl)-α-D-ribofuranosyl)acetonitrile (99232-86-7) + (S)-2-(2,4-dimethoxy-5-nitropyrimidin-6-yl)-2-(2,3-O-isopropylidene-5-O-(triphenylmethyl)-α-D-ribofuranosyl)acetonitrile (99232-87-8)

Guidance literature:

With sodium hydride; potassium iodide; Yield given. Multistep reaction; 1.) DME, a) 0 deg C - 20 deg C, b) 20 deg C, 60 min, 2.) DME, reflux, 90 min;

DOI:10.1021/jo00357a021

Reference yield: 31.0%

(R)-2-(2,4-dimethoxy-5-nitropyrimidin-6-yl)-2-(2,3-O-isopropylidene-5-O-(triphenylmethyl)-α-D-ribofuranosyl)acetonitrile (99232-86-7) → 2,4-dimethoxy-7-C-<2,3-O-isopropylidene-5-O-(triphenylmethyl)-α-D-ribofuranosyl>pyrrolo<3,2-d>pyrimidine (99232-88-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; at 90 ℃; for 24h; under 12928.7 Torr;

DOI:10.1021/jo00357a021

upstream raw materials:

4-cyanomethyl-2,6-dimethoxy-5-nitropyrimidine

2,3-O-Isopropylidene-5-O-trityl-α,β-ribofuranosyl chloride

Downstream raw materials:

2,4-dimethoxy-7-C-<2,3-O-isopropylidene-5-O-(triphenylmethyl)-α-D-ribofuranosyl>pyrrolo<3,2-d>pyrimidine