(2S,3R)-3-Benzyloxy-2-[(S)-2-({(2S,3R)-3-[(1R,2R)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-pentadecyl]-oxiranecarbonyl}-amino)-3-methyl-butyrylamino]-butyric acid allyl ester

Base Information

Chemical Name:(2S,3R)-3-Benzyloxy-2-[(S)-2-({(2S,3R)-3-[(1R,2R)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-pentadecyl]-oxiranecarbonyl}-amino)-3-methyl-butyrylamino]-butyric acid allyl ester
CAS No.:867038-90-2
Molecular Formula:C₄₄H₇₆N₂O₇Si
Molecular Weight:773.182
Hs Code.:

(2S,3R)-3-Benzyloxy-2-[(S)-2-({(2S,3R)-3-[(1R,2R)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-pentadecyl]-oxiranecarbonyl}-amino)-3-methyl-butyrylamino]-butyric acid allyl ester

Synonyms:(2S,3R)-3-Benzyloxy-2-[(S)-2-({(2S,3R)-3-[(1R,2R)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-pentadecyl]-oxiranecarbonyl}-amino)-3-methyl-butyrylamino]-butyric acid allyl ester

Suppliers and Price of (2S,3R)-3-Benzyloxy-2-[(S)-2-({(2S,3R)-3-[(1R,2R)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-pentadecyl]-oxiranecarbonyl}-amino)-3-methyl-butyrylamino]-butyric acid allyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of (2S,3R)-3-Benzyloxy-2-[(S)-2-({(2S,3R)-3-[(1R,2R)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-pentadecyl]-oxiranecarbonyl}-amino)-3-methyl-butyrylamino]-butyric acid allyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3R)-3-Benzyloxy-2-[(S)-2-({(2S,3R)-3-[(1R,2R)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-pentadecyl]-oxiranecarbonyl}-amino)-3-methyl-butyrylamino]-butyric acid allyl ester

There total 11 articles about (2S,3R)-3-Benzyloxy-2-[(S)-2-({(2S,3R)-3-[(1R,2R)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-pentadecyl]-oxiranecarbonyl}-amino)-3-methyl-butyrylamino]-butyric acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: (2S,3R)-2-((S)-2-Amino-3-methyl-butyrylamino)-3-benzyloxy-butyric acid allyl ester

: 623936-85-6
(2S,3R)-3-[(1R,2R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-pentadecyl]-oxirane-2-carboxylic acid

: 867038-90-2
(2S,3R)-3-Benzyloxy-2-[(S)-2-({(2S,3R)-3-[(1R,2R)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-pentadecyl]-oxiranecarbonyl}-amino)-3-methyl-butyrylamino]-butyric acid allyl ester

Guidance literature:: With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 25 ℃; for 1h;
DOI:10.1021/jo050625l

Reference yield:

: {3-[(1R,2R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-pentadecyl]-oxiranyl}-methanol

: 867038-90-2
(2S,3R)-3-Benzyloxy-2-[(S)-2-({(2S,3R)-3-[(1R,2R)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-pentadecyl]-oxiranecarbonyl}-amino)-3-methyl-butyrylamino]-butyric acid allyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 64 percent / NaIO₄; RuCl₃ / CCl₄; acetonitrile; H₂O / 0.5 h / 0 °C

2: 70 percent / 1-hydroxybenzotriazole hydrate; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 1 h / 25 °C

With ruthenium trichloride; sodium periodate; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrachloromethane; dichloromethane; water; acetonitrile;
DOI:10.1021/jo050625l

Reference yield:

: 124-25-4,511542-15-7
myristylaldehyde

: 867038-90-2
(2S,3R)-3-Benzyloxy-2-[(S)-2-({(2S,3R)-3-[(1R,2R)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-pentadecyl]-oxiranecarbonyl}-amino)-3-methyl-butyrylamino]-butyric acid allyl ester

Guidance literature:: Multi-step reaction with 11 steps

1.1: (n-Bu)2BOTf; Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

1.2: 85 percent / CH₂Cl₂ / 12 h / -78 °C

2.1: 92 percent / LiBH₄ / tetrahydrofuran / -20 - 0 °C

3.1: 94 percent / pyridine / CH₂Cl₂ / 0.67 h / -20 °C

4.1: 96 percent / imidazole / dimethylformamide / 12 h / 25 °C

5.1: 98 percent / DIBAL-H / CH₂Cl₂ / 0.5 h / -78 °C

6.1: 94 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 - 0 °C

7.1: 92 percent / benzene / 12 h / Heating

8.1: 98 percent / DIBAL-H / CH₂Cl₂ / 0.5 h / -78 °C

9.1: 91 percent / Ti(i-PrO)4; (-)-DET; TBHP / CH₂Cl₂; decane / 24 h / -20 °C

10.1: 64 percent / NaIO₄; RuCl₃ / CCl₄; acetonitrile; H₂O / 0.5 h / 0 °C

11.1: 70 percent / 1-hydroxybenzotriazole hydrate; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 1 h / 25 °C

With pyridine; 1H-imidazole; titanium(IV) isopropylate; tert.-butylhydroperoxide; ruthenium trichloride; sodium periodate; lithium borohydride; oxalyl dichloride; di-n-butylboryl trifluoromethanesulfonate; diisobutylaluminium hydride; dimethyl sulfoxide; (-)-diethyl tartrate; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; tetrachloromethane; decane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; benzene; 6.1: Swern oxidation / 9.1: Sharpless asymmetric epoxidation;
DOI:10.1021/jo050625l