(1S,4S,7S,10S,13R,14S,15R)-7-((R)-1-Benzyloxy-ethyl)-10-benzyloxymethyl-4-isopropyl-14-methyl-13-tridecyl-12,16-dioxa-3,6,9-triaza-bicyclo[13.1.0]hexadecane-2,5,8,11-tetraone

Base Information

Chemical Name:(1S,4S,7S,10S,13R,14S,15R)-7-((R)-1-Benzyloxy-ethyl)-10-benzyloxymethyl-4-isopropyl-14-methyl-13-tridecyl-12,16-dioxa-3,6,9-triaza-bicyclo[13.1.0]hexadecane-2,5,8,11-tetraone
CAS No.:623936-74-3
Molecular Formula:C₄₅H₆₇N₃O₈
Molecular Weight:778.042
Hs Code.:

(1S,4S,7S,10S,13R,14S,15R)-7-((R)-1-Benzyloxy-ethyl)-10-benzyloxymethyl-4-isopropyl-14-methyl-13-tridecyl-12,16-dioxa-3,6,9-triaza-bicyclo[13.1.0]hexadecane-2,5,8,11-tetraone

Synonyms:(1S,4S,7S,10S,13R,14S,15R)-7-((R)-1-Benzyloxy-ethyl)-10-benzyloxymethyl-4-isopropyl-14-methyl-13-tridecyl-12,16-dioxa-3,6,9-triaza-bicyclo[13.1.0]hexadecane-2,5,8,11-tetraone

Suppliers and Price of (1S,4S,7S,10S,13R,14S,15R)-7-((R)-1-Benzyloxy-ethyl)-10-benzyloxymethyl-4-isopropyl-14-methyl-13-tridecyl-12,16-dioxa-3,6,9-triaza-bicyclo[13.1.0]hexadecane-2,5,8,11-tetraone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1S,4S,7S,10S,13R,14S,15R)-7-((R)-1-Benzyloxy-ethyl)-10-benzyloxymethyl-4-isopropyl-14-methyl-13-tridecyl-12,16-dioxa-3,6,9-triaza-bicyclo[13.1.0]hexadecane-2,5,8,11-tetraone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1S,4S,7S,10S,13R,14S,15R)-7-((R)-1-Benzyloxy-ethyl)-10-benzyloxymethyl-4-isopropyl-14-methyl-13-tridecyl-12,16-dioxa-3,6,9-triaza-bicyclo[13.1.0]hexadecane-2,5,8,11-tetraone

There total 27 articles about (1S,4S,7S,10S,13R,14S,15R)-7-((R)-1-Benzyloxy-ethyl)-10-benzyloxymethyl-4-isopropyl-14-methyl-13-tridecyl-12,16-dioxa-3,6,9-triaza-bicyclo[13.1.0]hexadecane-2,5,8,11-tetraone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 623936-76-5
(2S,3R)-2-[(S)-2-({(2S,3R)-3-[(1S,2R)-2-((S)-2-Amino-3-benzyloxy-propionyloxy)-1-methyl-pentadecyl]-oxiranecarbonyl}-amino)-3-methyl-butyrylamino]-3-benzyloxy-butyric acid

: 623936-74-3
(1S,4S,7S,10S,13R,14S,15R)-7-((R)-1-Benzyloxy-ethyl)-10-benzyloxymethyl-4-isopropyl-14-methyl-13-tridecyl-12,16-dioxa-3,6,9-triaza-bicyclo[13.1.0]hexadecane-2,5,8,11-tetraone

Guidance literature:: With N-ethyl-N,N-diisopropylamine; diethyl dicarbonate; In N,N-dimethyl-formamide; at 25 ℃; for 12h;
DOI:10.1016/j.tetlet.2003.08.013

Reference yield: 19.0%

: (2S,3R)-3-((1S,2R)-2-{(S)-2-[(2S,3R)-2-((S)-2-Amino-3-methyl-butyrylamino)-3-benzyloxy-butyrylamino]-3-benzyloxy-propionyloxy}-1-methyl-pentadecyl)-oxirane-2-carboxylic acid; compound with trifluoro-acetic acid

: 623936-74-3
(1S,4S,7S,10S,13R,14S,15R)-7-((R)-1-Benzyloxy-ethyl)-10-benzyloxymethyl-4-isopropyl-14-methyl-13-tridecyl-12,16-dioxa-3,6,9-triaza-bicyclo[13.1.0]hexadecane-2,5,8,11-tetraone

Guidance literature:: With diethyl cyanophosphonate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 25 ℃; for 24h;
DOI:10.1021/jo050625l

Reference yield:

: 452956-81-9
(2S,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-hexadecanal

: 623936-74-3
(1S,4S,7S,10S,13R,14S,15R)-7-((R)-1-Benzyloxy-ethyl)-10-benzyloxymethyl-4-isopropyl-14-methyl-13-tridecyl-12,16-dioxa-3,6,9-triaza-bicyclo[13.1.0]hexadecane-2,5,8,11-tetraone

Guidance literature:: Multi-step reaction with 10 steps

1.1: 92 percent / benzene / 12 h / Heating

2.1: 98 percent / DIBAL-H / CH₂Cl₂ / 0.5 h / -78 °C

3.1: 91 percent / Ti(i-PrO)4; (-)-DET; TBHP / CH₂Cl₂; decane / 24 h / -20 °C

4.1: 64 percent / NaIO₄; RuCl₃ / CCl₄; acetonitrile; H₂O / 0.5 h / 0 °C

5.1: 70 percent / 1-hydroxybenzotriazole hydrate; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 1 h / 25 °C

6.1: HF*pyridine / tetrahydrofuran / 12 h / 25 °C

7.1: triethylamine; 2,4,6-trichlorobenzoyl chloride / tetrahydrofuran / 2 h / 0 °C

7.2: 86 percent / 4-dimethylaminopyridine / tetrahydrofuran; toluene / 0 - 25 °C

8.1: 94 percent / morpholine / Pd(PPh₃)4 / tetrahydrofuran / 0.5 h / 25 °C

9.1: CH₂Cl₂ / 1 h / 0 °C

10.1: 45 percent / diethyl cyanophosphonate; diisopropylethylamine / dimethylformamide / 24 h / 25 °C

With morpholine; titanium(IV) isopropylate; tert.-butylhydroperoxide; ruthenium trichloride; sodium periodate; diethyl cyanophosphonate; 2,4,6-trichlorobenzoyl chloride; diisobutylaluminium hydride; pyridine hydrogenfluoride; (-)-diethyl tartrate; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; tetrachloromethane; decane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; benzene; 3.1: Sharpless asymmetric epoxidation;
DOI:10.1021/jo050625l