9-[2-(1,1-dimethylethoxy)-2-oxoethyl]-2,2-dimethyl-4-oxo-6,12-bis(phenylmethyl)-3-oxa-6,9,12-triazatetradecan-14-oic acid 1,1-dimethylethyl ester

Base Information

• Chemical Name: 9-[2-(1,1-dimethylethoxy)-2-oxoethyl]-2,2-dimethyl-4-oxo-6,12-bis(phenylmethyl)-3-oxa-6,9,12-triazatetradecan-14-oic acid 1,1-dimethylethyl ester
• CAS No.: 662168-37-8
• Molecular Formula: C₃₆H₅₅N₃O₆
• Molecular Weight: 625.849
• Mol file: 662168-37-8.mol

Synonyms:9-[2-(1,1-dimethylethoxy)-2-oxoethyl]-2,2-dimethyl-4-oxo-6,12-bis(phenylmethyl)-3-oxa-6,9,12-triazatetradecan-14-oic acid 1,1-dimethylethyl ester

Chemical Property of 9-[2-(1,1-dimethylethoxy)-2-oxoethyl]-2,2-dimethyl-4-oxo-6,12-bis(phenylmethyl)-3-oxa-6,9,12-triazatetradecan-14-oic acid 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-[2-(1,1-dimethylethoxy)-2-oxoethyl]-2,2-dimethyl-4-oxo-6,12-bis(phenylmethyl)-3-oxa-6,9,12-triazatetradecan-14-oic acid 1,1-dimethylethyl ester

There total 8 articles about 9-[2-(1,1-dimethylethoxy)-2-oxoethyl]-2,2-dimethyl-4-oxo-6,12-bis(phenylmethyl)-3-oxa-6,9,12-triazatetradecan-14-oic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

tert-butyl 2-(benzyl-(2-bromoethyl)amino)-acetate (179188-09-1) + glycine tert-butyl ester hydrochloride (27532-96-3) → 9-[2-(1,1-dimethylethoxy)-2-oxoethyl]-2,2-dimethyl-4-oxo-6,12-bis(phenylmethyl)-3-oxa-6,9,12-triazatetradecan-14-oic acid 1,1-dimethylethyl ester (662168-37-8)

Guidance literature:

glycine tert-butyl ester hydrochloride; With potassium carbonate; In acetonitrile; for 1h; Reflux;

tert-butyl 2-(benzyl-(2-bromoethyl)amino)-acetate; In acetonitrile; for 24h; Reflux;

DOI:10.1002/ejoc.201800066

Reference yield: 79.0%

bromoacetic acid tert-butyl ester (5292-43-3) + N1-benzyl-N2-(2-(benzylamino)ethyl)ethane-1,2-diamine (17327-80-9) → 9-[2-(1,1-dimethylethoxy)-2-oxoethyl]-2,2-dimethyl-4-oxo-6,12-bis(phenylmethyl)-3-oxa-6,9,12-triazatetradecan-14-oic acid 1,1-dimethylethyl ester (662168-37-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 48h;

DOI:10.1002/ejoc.201800066

Reference yield: 79.0%

bromoacetic acid tert-butyl ester (5292-43-3) + N-(phenylmethyl)-N'-[2-[(phenylmethyl)amino]ethyl]-1,2-ethanediamine trihydrochloride (17327-82-1) → 9-[2-(1,1-dimethylethoxy)-2-oxoethyl]-2,2-dimethyl-4-oxo-6,12-bis(phenylmethyl)-3-oxa-6,9,12-triazatetradecan-14-oic acid 1,1-dimethylethyl ester (662168-37-8)

Guidance literature:

With potassium carbonate; In acetonitrile; for 2h; Heating;

DOI:10.1021/jo0480242

upstream raw materials:

bromoacetic acid tert-butyl ester

N-(phenylmethyl)-N'-[2-[(phenylmethyl)amino]ethyl]-1,2-ethanediamine trihydrochloride

benzaldehyde

N¹-benzyl-N²-(2-(benzylamino)ethyl)ethane-1,2-diamine