17327-80-9

Usage

Uses

Used in Organic Synthesis:
N-BENZYL-N'-(2-BENZYLAMINO-ETHYL)-ETHANE-1,2-DIAMINE is used as a reactant for the synthesis of various organic compounds due to its ability to participate in a range of chemical reactions, facilitating the creation of diverse molecular structures.
Used in Pharmaceutical Research:
In the pharmaceutical industry, N-BENZYL-N'-(2-BENZYLAMINO-ETHYL)-ETHANE-1,2-DIAMINE is utilized as a building block for the development of new drugs, contributing to the discovery of innovative therapeutic agents.
Used in Polymer Production:
N-BENZYL-N'-(2-BENZYLAMINO-ETHYL)-ETHANE-1,2-DIAMINE is used as a monomer or a component in the synthesis of polymers, which are essential materials in various industries, including plastics, textiles, and coatings.
Used in Agrochemicals:
N-BENZYL-N'-(2-BENZYLAMINO-ETHYL)-ETHANE-1,2-DIAMINE is used in the formulation of agrochemicals, such as pesticides and fertilizers, to enhance crop protection and yield.
Used in Coordination Chemistry:
As a ligand, N-BENZYL-N'-(2-BENZYLAMINO-ETHYL)-ETHANE-1,2-DIAMINE is employed in the synthesis of coordination compounds, which have applications in catalysis, materials science, and medicinal chemistry.
Used in Chemical Industry:
N-BENZYL-N'-(2-BENZYLAMINO-ETHYL)-ETHANE-1,2-DIAMINE's versatility and reactivity make it a valuable asset in the chemical industry for the development of new processes and products.

Upstream product

• 19093-67-5 (7E)-N**⁽¹⁾-benzylidene-N**⁽²⁾[(E)-2-(benzylideneamino)ethyl]ethane-1,2-diamine 
• 100-52-7 benzaldehyde 
• 111-40-0 3-azapentane-1,5-diamine 
• 100-39-0 benzyl bromide 
• 185558-33-2 1,7-Dibenzyl-N,N',N''-tritosyl-1,4,7-triazaheptadecane 

Downstream Products

• 1266551-15-8 (NH(CH₂CH₂NHCH₂C₆H₅)2)Cu(NCCH₃)⁽¹⁺⁾*PF₆^(1-)=[(NH(CH₂CH₂NHCH₂C₆H₅)2)Cu(NCCH₃)]PF₆ 
• 1332368-11-2 N,N''-[(benzyl)-N,N',N''-[(6-methoxycarbonyl)pyridine-2-yl]methyl]diethylenetriamine 
• 662168-37-8 9-[2-(1,1-dimethylethoxy)-2-oxoethyl]-2,2-dimethyl-4-oxo-6,12-bis(phenylmethyl)-3-oxa-6,9,12-triazatetradecan-14-oic acid 1,1-dimethylethyl ester 

Relevant academic research and scientific papers

Concerning two-metal cooperativity in model phosphate hydrolysis

Three series of bimetallic ligands were tested for cooperativity in the hydrolysis of phosphate esters. It was shown that rate enhancements were in part contributed by binding to the hydrophobic linkers when the substrates were also hydrophobic, and two metal cooperativity was not found to be present. Kinetic order tests were performed and shown to be superior to previous methods for analyzing cooperativity.

Hexazamacrocycle assisted sensing of silver ion through facile synthesis of silver nanoparticles

The ease of generation of silver nanoparticles by using hexazamacrocycle ligand, L1 is utilized for the visual detection of the presence of silver ions at lower concentrations.

Facile Access to the 12-Membered Macrocyclic Ligand PCTA and Its Derivatives with Carboxylate, Amide, and Phosphinate Ligating Functionalities

We describe a convenient synthetic pathway to access the 12-membered PCTA macrocycle, a polyaminocarboxylate ligand for which its M2+ and M3+ complexes are commonly associated with applications in biomedical diagnostics and radiother

High-denticity ligands based on picolinic acid for 111In radiochemistry

Four new acyclic ligands, Bn-H3nonapa (3), H3nonapa (4), p-NO2-Bn-H3nonapa (10), and Bn-H3trenpa (7), were synthesized and studied with nonradioactive In3+ and with radioactive 111/su

H4octapa: An acyclic chelator for 111In radiopharmaceuticals

This preliminary investigation of the octadentate acyclic chelator H 4octapa (N4O4) with 111In/ 115In3+ has demonstrated it to be an improvement on the shortcomings of the current industry "gold standards" DOTA (N 4O4) and DTPA (N3O5). The ability of H4octapa to radiolabel quantitatively 111InCl3 at ambient temperature in 10 min with specific activities as high as 2.3 mCi/nmol (97.5% radiochemical yield) is presented. In vitro mouse serum stability assays have demonstrated the 111In complex of H 4octapa to have improved stability when compared to DOTA and DTPA over 24 h. Mouse biodistribution studies have shown that the radiometal complex [111In(octapa)]- has exceptionally high in vivo stability over 24 h with improved clearance and stability compared to [ 111In(DOTA)]-, demonstrated by lower uptake in the kidneys, liver, and spleen at 24 h. 1H/13C NMR studies of the [In(octapa)]- complex revealed a 7-coordinate solution structure, which forms a single isomer and exhibits no observable fluxional behavior at ambient temperature, an improvement to the multiple isomers formed by [In(DTPA)]2- and [In(DOTA)]- under the same conditions. Potentiometric titrations have determined the thermodynamic formation constant of the [In(octapa)]- complex to be log KML = 26.8(1). Through the same set of analyses, the [111/115In(decapa)] 2- complex was found to have nonoptimal stability, with H 5decapa (N5O5) being more suitable for larger metal ions due to its higher potential denticity (e.g., lanthanides and actinides). Our initial investigations have revealed the acyclic chelator H 4octapa to be a valuable alternative to the macrocycle DOTA for use with 111In, and a significant improvement to the acyclic chelator DTPA.

BIFUNCTIONAL CHELATING AGENTS

A bifunctional chelating agent of the formula (I): wherein the variables R1, R1 , Q1, Q2 and M are as defined in the description of the present application. Also described is a complex of the above chelating age

Syntheses, characterization and properties of open-chain copper(I) complexes

The coordination chemistry of copper complexes with theligand L1 [L1 = {7E}-N1-benzylidene-N2-{(E)-2- (benzylideneamino)ethyl}ethane-1,2-diamine] has been investigated. For copper(I) complexes of L1,

Supramolecular catalysis of H/D exchange in pyruvate by macrocyclic polyamines involving a reactive iminium intermediate

The activity of a series of macrocyclic polyamines as catalysts for proton exchange has been investigated. Structural and physico-chemical studies demonstrate the ability of these receptors to recognize pyruvate, form a covalent iminium intermediate and catalyse H/D exchange at the CH3 position. The reaction follows Michaelis-Menten kinetics with a rate enhancement higher than 4.8 × 105 (kcat/kuncat). The process also represents a potential entry into the catalysis of aldol condensation reactions.