(2S,4R)-tert-butyl 4-hydroxy-2-(methoxydiphenylmethyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:(2S,4R)-tert-butyl 4-hydroxy-2-(methoxydiphenylmethyl)pyrrolidine-1-carboxylate
CAS No.:866011-43-0
Molecular Formula:C₂₃H₂₉NO₄
Molecular Weight:383.488
Hs Code.:

Synonyms:(2S,4R)-tert-butyl 4-hydroxy-2-(methoxydiphenylmethyl)pyrrolidine-1-carboxylate

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Chemical Property of (2S,4R)-tert-butyl 4-hydroxy-2-(methoxydiphenylmethyl)pyrrolidine-1-carboxylate

Chemical Property:

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Technology Process of (2S,4R)-tert-butyl 4-hydroxy-2-(methoxydiphenylmethyl)pyrrolidine-1-carboxylate

There total 4 articles about (2S,4R)-tert-butyl 4-hydroxy-2-(methoxydiphenylmethyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 866011-42-9
4-(tert-butyl-dimethyl-silanyloxy)-2-(methoxy-diphenyl-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

: 866011-43-0
(2S,4R)-tert-butyl 4-hydroxy-2-(methoxydiphenylmethyl)pyrrolidine-1-carboxylate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/ol0517729

Reference yield:

: 866011-41-8
4-(tert-butyl-dimethyl-silanyloxy)-2-(hydroxy-diphenyl-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

: 866011-43-0
(2S,4R)-tert-butyl 4-hydroxy-2-(methoxydiphenylmethyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 61 percent / NaH / tetrahydrofuran / 20 °C

2: 100 percent / TBAF / tetrahydrofuran / 20 °C

With tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran;
DOI:10.1021/ol0517729

Reference yield:

: phenylmagnesium bromide

: 866011-43-0
(2S,4R)-tert-butyl 4-hydroxy-2-(methoxydiphenylmethyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / -78 - 20 °C

2: 61 percent / NaH / tetrahydrofuran / 20 °C

3: 100 percent / TBAF / tetrahydrofuran / 20 °C

With tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran;
DOI:10.1021/ol0517729