(2S,4R)-2-(methoxydiphenylmethyl)-4-{4-[1-(2,2,6,6-tetramethylpiperidin-1-yloxy)ethyl]benzyloxy}pyrrolidine-1-carboxylic acid tert-butyl estr

Base Information

• Chemical Name: (2S,4R)-2-(methoxydiphenylmethyl)-4-{4-[1-(2,2,6,6-tetramethylpiperidin-1-yloxy)ethyl]benzyloxy}pyrrolidine-1-carboxylic acid tert-butyl estr
• CAS No.: 1061611-28-6
• Molecular Formula: C₄₁H₅₆N₂O₅
• Molecular Weight: 656.906
• Mol file: 1061611-28-6.mol

Synonyms:(2S,4R)-2-(methoxydiphenylmethyl)-4-{4-[1-(2,2,6,6-tetramethylpiperidin-1-yloxy)ethyl]benzyloxy}pyrrolidine-1-carboxylic acid tert-butyl estr

Chemical Property of (2S,4R)-2-(methoxydiphenylmethyl)-4-{4-[1-(2,2,6,6-tetramethylpiperidin-1-yloxy)ethyl]benzyloxy}pyrrolidine-1-carboxylic acid tert-butyl estr

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,4R)-2-(methoxydiphenylmethyl)-4-{4-[1-(2,2,6,6-tetramethylpiperidin-1-yloxy)ethyl]benzyloxy}pyrrolidine-1-carboxylic acid tert-butyl estr

There total 1 articles about (2S,4R)-2-(methoxydiphenylmethyl)-4-{4-[1-(2,2,6,6-tetramethylpiperidin-1-yloxy)ethyl]benzyloxy}pyrrolidine-1-carboxylic acid tert-butyl estr which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

(2S,4R)-tert-butyl 4-hydroxy-2-(methoxydiphenylmethyl)pyrrolidine-1-carboxylate (866011-43-0) + 1-[1-(4-iodomethylphenyl)ethoxy]-2,2,6,6-tetramethylpiperidine (845728-30-5) → (2S,4R)-2-(methoxydiphenylmethyl)-4-{4-[1-(2,2,6,6-tetramethylpiperidin-1-yloxy)ethyl]benzyloxy}pyrrolidine-1-carboxylic acid tert-butyl estr (1061611-28-6)

Guidance literature:

(2S,4R)-tert-butyl 4-hydroxy-2-(methoxydiphenylmethyl)pyrrolidine-1-carboxylate; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; Reflux;

1-[1-(4-iodomethylphenyl)ethoxy]-2,2,6,6-tetramethylpiperidine; In tetrahydrofuran; mineral oil; at 20 ℃; Reflux;

DOI:10.1055/s-2008-1067146

Reference yield: 75.0%

(2S,4R)-2-(methoxydiphenylmethyl)-4-{4-[1-(2,2,6,6-tetramethylpiperidin-1-yloxy)ethyl]benzyloxy}pyrrolidine-1-carboxylic acid tert-butyl estr (1061611-28-6) → 1-(1-{4-[(3R,5S)-5-(methoxydiphenylmethyl)pyrrolidin-3-yl-oxymethyl]phenyl}ethoxy)-2,2,6,6-tetramethylpiperidine (1061611-25-3)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water; at 0 ℃; for 4h;

DOI:10.1055/s-2008-1067146

upstream raw materials:

(2S,4R)-tert-butyl 4-hydroxy-2-(methoxydiphenylmethyl)pyrrolidine-1-carboxylate

1-[1-(4-iodomethylphenyl)ethoxy]-2,2,6,6-tetramethylpiperidine

Downstream raw materials:

1-(1-{4-[(3R,5S)-5-(methoxydiphenylmethyl)pyrrolidin-3-yl-oxymethyl]phenyl}ethoxy)-2,2,6,6-tetramethylpiperidine