Technology Process of ethyl (+/-)-4-(1-((3-methylquinolin-2-yl)amino)butyl)benzoate
There total 5 articles about ethyl (+/-)-4-(1-((3-methylquinolin-2-yl)amino)butyl)benzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate;
In
dichloromethane;
at 20 ℃;
for 12h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide; dichloromethane / 3 h / 0 - 20 °C
2: sodium cyanoborohydride; ammonium acetate / methanol / 16 h / 60 °C
3: bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 20 °C
With
ammonium acetate; sulfur trioxide pyridine complex; sodium cyanoborohydride; triethylamine; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate;
In
methanol; dichloromethane; dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: TurboGrignard / tetrahydrofuran / 0.67 h / -40 °C
1.2: 3 h / -40 - 20 °C
2.1: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide; dichloromethane / 3 h / 0 - 20 °C
3.1: sodium cyanoborohydride; ammonium acetate / methanol / 16 h / 60 °C
4.1: bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 20 °C
With
TurboGrignard; ammonium acetate; sulfur trioxide pyridine complex; sodium cyanoborohydride; triethylamine; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate;
In
tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide;
