1-(4-chlorophenyl)-4-(hydroxymethyl)-N-(3-methoxy-4-(2-((2-(trimethylsilyl)ethoxy)methoxy)propoxy)phenyl)-1H-pyrazole-3-carboxamide

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Chemical Name:1-(4-chlorophenyl)-4-(hydroxymethyl)-N-(3-methoxy-4-(2-((2-(trimethylsilyl)ethoxy)methoxy)propoxy)phenyl)-1H-pyrazole-3-carboxamide
CAS No.:1224172-02-4
Molecular Formula:C₂₇H₃₆ClN₃O₆Si
Molecular Weight:562.138
Hs Code.:

Synonyms:1-(4-chlorophenyl)-4-(hydroxymethyl)-N-(3-methoxy-4-(2-((2-(trimethylsilyl)ethoxy)methoxy)propoxy)phenyl)-1H-pyrazole-3-carboxamide

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Chemical Property of 1-(4-chlorophenyl)-4-(hydroxymethyl)-N-(3-methoxy-4-(2-((2-(trimethylsilyl)ethoxy)methoxy)propoxy)phenyl)-1H-pyrazole-3-carboxamide

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Technology Process of 1-(4-chlorophenyl)-4-(hydroxymethyl)-N-(3-methoxy-4-(2-((2-(trimethylsilyl)ethoxy)methoxy)propoxy)phenyl)-1H-pyrazole-3-carboxamide

There total 4 articles about 1-(4-chlorophenyl)-4-(hydroxymethyl)-N-(3-methoxy-4-(2-((2-(trimethylsilyl)ethoxy)methoxy)propoxy)phenyl)-1H-pyrazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1224172-01-3
ethyl 1-(4-chlorophenyl)-3-(3-methoxy-4-(2-((2-(trimethylsilyl)ethoxy)methoxy)propoxy)phenylcarbamoyl)-1H-pyrazole-4-carboxylate

: 1224172-02-4
1-(4-chlorophenyl)-4-(hydroxymethyl)-N-(3-methoxy-4-(2-((2-(trimethylsilyl)ethoxy)methoxy)propoxy)phenyl)-1H-pyrazole-3-carboxamide

Guidance literature:: With lithium borohydride; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1016/j.bmcl.2015.05.008

Reference yield:

: C₁₅H₁₂Cl₂N₂O₂

: 1224172-02-4
1-(4-chlorophenyl)-4-(hydroxymethyl)-N-(3-methoxy-4-(2-((2-(trimethylsilyl)ethoxy)methoxy)propoxy)phenyl)-1H-pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / isopropyl alcohol / 2 h / 80 °C

2: hydrogen; palladium 10% on activated carbon / ethyl acetate / 5 h / 20 °C

3: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 4.5 h / 20 °C

4: lithium borohydride / tetrahydrofuran / 2 h / 20 °C

With lithium borohydride; palladium 10% on activated carbon; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; ethyl acetate; isopropyl alcohol;
DOI:10.1016/j.bmcl.2015.05.008

Reference yield:

: 1224171-94-1
1-(4-chlorophenyl)-4-(ethoxycarbonyl)-1H-pyrazole-3-carboxylic acid

: 1224172-02-4
1-(4-chlorophenyl)-4-(hydroxymethyl)-N-(3-methoxy-4-(2-((2-(trimethylsilyl)ethoxy)methoxy)propoxy)phenyl)-1H-pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 4.5 h / 20 °C

2: lithium borohydride / tetrahydrofuran / 2 h / 20 °C

With lithium borohydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2015.05.008